Generalized Anxiety Disorder is Prospectively Associated With Decreased Levels of Interleukin-6 and Adiponectin Among Individuals from the Community

JOURNAL OF AFFECTIVE DISORDERS

卷:270

Article

Wagner, En-Young N.^1,2  Strippoli, Marie-Pierre F.^3,4  Ajdacic-Gross, Vladeta⁵  Gholam-Rezaee, Mehdi^3,4  Glaus, Jennifer^4,6  Vandeleur, Caroline^3,4  Vollenweider, Peter^4,7  Preisig, Martin^3,4  von Kanel, Roland¹ 

[1] Univ Zurich, Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland

[2] Bern Univ Hosp, Dept BioMed Res, Bern, Switzerland

[3] Lausanne Univ Hosp, Ctr Res Psychiat Epidemiol & Psychopathol, Dept Psychiat, Lausanne, Switzerland

[4] Univ Lausanne, Lausanne, Switzerland

[5] Univ Zurich, Psychiat Hosp, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland

[6] Lausanne Univ Hosp, Dept Psychiat, Serv Child & Adolescent Psychiat, Lausanne, Switzerland

[7] Lausanne Univ Hosp, Dept Med, Internal Med, Lausanne, Switzerland

关键词: Generalized anxiety disorder;    cardiovascular diseases;    inflammation;    interleukin-6;    adiponectin;    cohort study;   

DOI  :  10.1016/j.jad.2020.03.123

来源: Elsevier

【 摘 要 】

Background: Anxiety disorders have been related to cardiovascular diseases via low-grade inflammation, but longitudinal studies on the association between generalized anxiety disorder (GAD) and inflammatory biomarkers are sparse. Furthermore, no studies have examined the association between GAD and the cardioprotective adipocytokine adiponectin in this context so far. Methods: In a Swiss population-based sample of 2,415 adults participating in baseline and follow-up exams (mean follow-up duration=5.5 years), we diagnosed a total of 55 persons (2.3%) with GAD using a validated semi-structured psychiatric interview. We prospectively examined the relation between GAD and circulating levels of inflammatory biomarkers (i.e., C-reactive protein, interleukin (IL)-1 beta, IL-6, tumor necrosis factor-alpha, and adiponectin), in linear regression models, statistically controlled for the baseline inflammatory marker, socio-economic status, cardiovascular risk factors, health behaviors, and psychiatric disorders. Results: Compared to those without GAD, individuals with GAD had lower IL-6 (beta=-0.249, 95%-CI -0.493-(-0.004), p=0.046), and adiponectin (beta=-0.264, 95%-CI -0.482-(-0.045), p=0.018) levels at follow-up after adjustment for all covariates. Moreover, GAD was unrelated to several other inflammatory measures. Conclusion: Individuals with GAD do not seem to exhibit chronic low-grade inflammation, suggesting different underlying biobehavioral mechanisms to those from other anxiety disorders. Low adiponectin levels may be linked to symptoms of GAD through brain areas directly involved in the processing of fear and anxiety.

【 授权许可】

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