Statin Trials, Cardiovascular Events, and Coronary Artery Calcification Implications for a Trial-Based Approach to Statin Therapy in MESA

JACC-CARDIOVASCULAR IMAGING

卷:11

Article

Mortensen, Martin Bodtker¹  Falk, Erling¹  Li, Dong²  Nasir, Khurram^3,4,5,6  Blaha, Michael J.⁶  Sandfort, Veit⁷  Rodriguez, Carlos Jose⁸  Ouyang, Pamela⁹  Budoff, Matthew² 

[1] Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark

[2] Univ Calif Los Angeles, Dept Cardiol, Los Angeles Biomed Res Inst, Harbor UCLA, Torrance, CA USA

[3] Baptist Hlth South Florida, Ctr Healthcare Adv & Outcomes, Miami, FL USA

[4] Florida Int Univ, Dept Epidemiol, Robert Stempel Coll Publ Hlth, Herbert Wertheim Coll Med, Miami, FL 33199 USA

[5] Florida Int Univ, Dept Med, Herbert Wertheim Coll Med, Miami, FL 33199 USA

[6] Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA

[7] NIH, Radiol & Imaging Sci, Bldg 10, Bethesda, MD 20892 USA

[8] Wake Forest Sch Med, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Winston Salem, NC USA

[9] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

关键词: cardiovascular disease;    guideline;    lipoproteins;    primary prevention;    statin;   

DOI  :  10.1016/j.jcmg.2017.01.029

来源: Elsevier

【 摘 要 】

OBJECTIVES This study sought to determine whether coronary artery calcium (CAC) could be used to optimize statin allocation among individuals for whom trial-based evidence supports efficacy of statin therapy. BACKGROUND Recently, allocation of statins was proposed for primary prevention of atherosclerotic cardiovascular disease (ASCVD) based on proven efficacy from randomized controlled trials (RCTs) of statin therapy, a so-called trial-based approach. METHODS The study used data from MESA (Multi-Ethnic Study of Atherosclerosis) with 5,600 men and women, 45 to 84 years of age, and free of clinical ASCVD, lipid-lowering therapy, or missing information for risk factors at baseline examination. RESULTS During 10 years' follow-up, 354 ASCVD and 219 hard coronary heart disease (CHD) events occurred. Based on enrollment criteria for 7 RCTs of statin therapy in primary prevention, 73% of MESA participants (91% of those >55 years of age) were eligible for statin therapy according to a trial-based approach. Among those individuals, CAC = 0 was common (44%) and was associated with low rates of ASCVD and CHD (3.9 and 1.7, respectively, per 1,000 person-years). There was a graded increase in event rates with increasing CAC score, and in individuals with CAC > 100 (27% of participants) the rates of ASCVD and CHD were 18.9 and 12.7, respectively. Consequently, the estimated number needed to treat (NNT) in 10 years to prevent 1 event varied greatly according to CAC score. For ASCVD events, the NNT was 87 for CAC = 0 and 19 for CAC > 100. For CHD events, the NNT was 197 for CAC = 0 and 28 for CAC > 100. CONCLUSIONS Most MESA participants qualified for trial-based primary prevention with statins. Among the individuals for whom trial-based evidence supports efficacy of statin therapy, CAC = 0 and CAC > 100 were common and associated with low and high cardiovascular risks, respectively. This information may guide shared decision making aimed at targeting evidence-based statins to those who are likely to benefit the most. (C) 2018 by the American College of Cardiology Foundation.

【 授权许可】

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