JACC-CARDIOVASCULAR IMAGING | 卷:10 |
Coronary Atherosclerosis T1-Weighed Characterization With Integrated Anatomical Reference Comparison With High-Risk Plaque Features Detected by Invasive Coronary Imaging | |
Article | |
Xie, Yibin1,2  Kim, Young-Jin3  Pang, Jianing1  Kim, Jung-Sun4  Yang, Qi1  Wei, Janet1  Nguyen, Christopher T.1,2  Deng, Zixin1,2  Choi, Byoung Wook3  Fan, Zhaoyang1  Merz, C. Noel Bairey5  Shah, Prediman K.5  Berman, Daniel S.1,5  Chang, Hyuk-Jae4,6  Li, Debiao1,2  | |
[1] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, 8700 Beverly Blvd,PACT Suite 800, Los Angeles, CA 90048 USA | |
[2] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA USA | |
[3] Yonsei Univ, Coll Med, Severance Hosp, Dept Radiol, Seoul, South Korea | |
[4] Yonsei Univ, Coll Med, Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea | |
[5] Cedars Sinai Med Ctr, Heart Inst, Los Angeles, CA 90048 USA | |
[6] Yonsei Univ, Coll Med, Biomed Imaging Inst, Seoul, South Korea | |
关键词: atherosclerosis; inflammation; intraplaque hemorrhage; magnetic resonance imaging; optical coherence tomography; | |
DOI : 10.1016/j.jcmg.2016.06.014 | |
来源: Elsevier | |
【 摘 要 】
OBJECTIVES The aim of this work is the development of coronary atherosclerosis T1-weighted characterization with integrated anatomical reference (CATCH) technique and the validation by comparison with high-risk plaque features (HRPF) observed on intracoronary optical coherence tomography (OCT) and invasive coronary angiography. BACKGROUND T1-weighted cardiac magnetic resonance with or without contrast media has been used for characterizing coronary atherosclerosis showing promising prognostic value. Several limitations include: 1) coverage is limited to proximal coronary segments; 2) spatial resolution is low and often anisotropic; and 3) a separate magnetic resonance angiography acquisition is needed to localize lesions. METHODS CATCH acquired dark-blood T1-weighted images and bright-blood anatomical reference images in an interleaved fashion. Retrospective motion correction with 100% respiratory gating efficiency was achieved. Reference control subjects (n = 13) completed both pre-and post-contrast scans. Stable angina patients (n = 30) completed pre-contrast scans, among whom 26 eligible patients also completed post-contrast scans. After cardiac magnetic resonance, eligible patients (n = 22) underwent invasive coronary angiography and OCT for the interrogation of coronary atherosclerosis. OCT images were assessed and scored for HRPF (lipid-richness, macrophages, cholesterol crystals, and microvessels) by 2 experienced analysts blinded to magnetic resonance results. RESULTS Per-subject analysis showed none of the 13 reference control subjects had coronary hyperintensive plaques (CHIP) in either pre-contrast or post-contrast CATCH. Five patients had CHIP on pre-contrast CATCH and 5 patients had CHIP on post-contrast CATCH. Patients with CHIP had greater lipid abnormality than those without. Per-segment analysis showed elevated pre-and post-contrast plaque to myocardium signal ratio in the lesions with HRPF versus those without. Positive correlation was observed between plaque to myocardium signal ratio and OCT HRPF scoring. CHIP on pre-contrast CATCH were associated with significantly higher stenosis level than non-CHIP on invasive coronary angiography. CONCLUSIONS CATCH provided accelerated whole heart coronary plaque characterization with simultaneously acquired anatomical reference. CHIP detected by CATCH showed positive association with high-risk plaque features on invasive imaging studies. (C) 2017 by the American College of Cardiology Foundation.
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