Splenic Metabolic Activity Predicts Risk of Future Cardiovascular Events

JACC-CARDIOVASCULAR IMAGING

卷:8

Article

Emami, Hamed^1,2  Singh, Parmanand^1,2  MacNabb, Megan^1,2  Vucic, Esad^1,2  Lavender, Zachary^1,2  Rudd, James H. F.³  Fayad, Zahi A.⁴  Lehrer-Graiwer, Joshua⁵  Korsgren, Magnus⁶  Figueroa, Amparo L.^1,2  Fredrickson, Jill⁵  Rubin, Barry⁷  Hoffmann, Udo^1,2  Truong, Quynh A.^1,2  Min, James K.^8,9,10  Baruch, Amos⁵  Nasir, Khurram¹¹  Nahrendorf, Matthias^2,12  Tawakol, Ahmed^1,2,13 

[1] Massachusetts Gen Hosp, Div Cardiac Imaging, Cardiac MR PET CT Program, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Univ Cambridge, Div Cardiovasc Med, Cambridge, England

[4] Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, New York, NY 10029 USA

[5] Genentech Inc, San Francisco, CA 94080 USA

[6] BioInvent Int AB, Lund, Sweden

[7] Univ Toronto, Toronto Gen Hosp, Div Vasc Surg, Peter Munk Cardiac Ctr, Toronto, ON M5G 1L7, Canada

[8] Weill Cornell Med Coll, Dept Radiol, New York, NY USA

[9] Weill Cornell Med Coll, Dept Med, New York, NY USA

[10] New York Presbyterian Hosp, New York, NY USA

[11] Baptist Hlth South Florida, Miami, FL USA

[12] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[13] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA

关键词: acute coronary syndrome;    atherosclerosis;    events;    FDG;    inflammation;    spleen;   

DOI  :  10.1016/j.jcmg.2014.10.009

来源: Elsevier

【 摘 要 】

OBJECTIVES This study sought to determine whether splenic activation after acute coronary syndrome (ACS) is linked to leukocyte proinflammatory remodeling and whether splenic activity independently predicts the risk of cardiovascular disease (CVD) events. BACKGROUND Pre-clinical data suggest the existence of a cardiosplenic axis, wherein activation of hematopoietic tissues (notably in the spleen) results in Liberation of proinflammatory leukocytes and accelerated atherosclerotic inflammation. However, it is presently unknown whether a cardiosplenic axis exists in humans and whether splenic activation relates to CVD risk. METHODS F-18-fluorodeoxyglucose ((18)FDG)-positron emission tomography (PET) imaging was performed in 508 individuals across 2 studies. In the first study, we performed FDG-PET imaging in 22 patients with recent ACS and 22 control subjects. FDG uptake was measured in spleen and arterial wall, whereas proinflammatory gene expression of circulating leukocytes was assessed by quantitative real-time polymerase chain reaction. In a second study, we examined the relationship between splenic tissue FDG uptake with subsequent CVD events during follow-up (median 4 years) in 464 patients who previously had undergone FDG-PET imaging. RESULTS Splenic activity increased after ACS and was significantly associated with multiple indices of inflammation: 1) up-regulated gene expression of proinflammatory leukocytes; 2) increased C-reactive protein; and 3) increased arterial wall inflammation (FDG uptake). Moreover, in the second study, splenic activity (greater than or equal to the median) was associated with an increased risk of CVD events (hazard ratio [HR]: 3.3; 95% confidence interval [CI]: 1.5 to 7.3; p = 0.003), which remained significant after adjustment for CVD risk factors (HR: 2.26; 95% CI: 1.01 to 5.06; p = 0.04) and for arterial FDG uptake (HR: 2.68; 95% CI: 1.5 to 7.4; p = 0.02). CONCLUSIONS Our findings demonstrate increased splenic metabolic activity after ACS and its association with proinflammatory remodeling of circulating leukocytes. Moreover, we observed that metabolic activity of the spleen independently predicted risk of subsequent CVD events. Collectively, these findings provide evidence of a cardiosplenic axis in humans similar to that shown in pre-clinical studies. (C) 2015 by the American College of Cardiology Foundation.

【 授权许可】

Free