Validation and Characterization of Transcatheter Aortic Valve Effective Orifice Area Measured by Doppler Echocardiography

JACC-CARDIOVASCULAR IMAGING

卷:4

Article

Clavel, Marie-Annick¹  Rodes-Cabau, Josep¹  Dumont, Eric¹  Bagur, Rodrigo¹  Bergeron, Sebastien¹  De Larochelliere, Robert¹  Doyle, Daniel¹  Larose, Eric¹  Dumesnil, Jean G.¹  Pibarot, Philippe¹ 

[1] Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec Heart & Lung Inst, Quebec City, PQ G1V 4G5, Canada

关键词: aortic stenosis;    echocardiography;    prosthesis;    transcatheter;    valves;   

DOI  :  10.1016/j.jcmg.2011.06.021

来源: Elsevier

【 摘 要 】

OBJECTIVES The objectives were to compare different Doppler echocardiographic methods for the measurement of prosthetic valve effective orifice area (EOA) following transcatheter aortic valve implantation (TAVI) and to determine the factors influencing the EOA of transcatheter balloon expandable valves. BACKGROUND Previous studies have used different methods for the measurement of the valve EOA following TAVI. Factors influencing the EOA of transcatheter valves are unknown. METHODS A total of 122 patients underwent TAVI with the use of the Edwards-SAPIEN valve (Edwards Lifesciences, Irvine, California). The EOA was measured by transthoracic echocardiography at hospital discharge, 6 months and 1 year after TAVI with the use of 2 methods as described in previous studies. In Method #1 (EOA(1)), LVOT diameter (LVOTd) entered in the continuity equation was measured at the base of prosthesis cusps whereas, in Method #2 (EOA(2)), LVOTd was measured immediately proximal to the prosthesis stent. RESULTS The average EOA(2) (1.57 +/- 0.41 cm(2)) was larger (p < 0.01) than the EOA(1) (1.21 +/- 0.38 cm(2)). Accordingly, incidence of severe PPM (indexed EOA <= 0.65 cm(2)/m(2)) was 3-fold lower with the use of EOA(2) than with EOA(1) (9% vs. 33%; p < 0.001). Mean transprosthetic gradient correlated better (p = 0.03) with indexed EOA(2) (r = -0.70, p < 0.0001) than with indexed EOA(1) (r = -0.58, p < 0.0001). Intraobserver and interobserver variability were lower for EOA(2) compared to EOA(1) (intra: 5% vs. 7%, p = 0.06; inter: 6% vs. 14%; p < 0.001). Aortic annulus size was the sole independent determinant (p = 0.01) of prosthetic valve EOA(2). The average EOA varied from 1.37 +/- 0.23 cm(2) for aortic annulus size <19 mm up to 1.90 +/- 0.17 cm(2) for size >23 mm. CONCLUSIONS When estimating the EOA of Edwards-SAPIEN valves by Doppler-echocardiography, it is recommended to use the LVOT diameter and velocity measured immediately proximal to the stent. The main determinant of the EOA of transcatheter valves is the patient's annulus size and these valves provide excellent hemodynamics even in patients with a small aortic annulus. (J Am Coll Cardiol Img 2011;4:1053-62) (C) 2011 by the American College of Cardiology Foundation

【 授权许可】

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