OCT Compared With IVUS in a Coronary Lesion Assessment The OPUS-CLASS Study

JACC-CARDIOVASCULAR IMAGING

卷:6

Article

Kubo, Takashi¹  Akasaka, Takashi¹  Shite, Junya²  Suzuki, Takahiko³  Uemura, Shiro⁴  Yu, Bo⁵  Kozuma, Ken⁶  Kitabata, Hironori¹  Shinke, Toshiro²  Habara, Maoto³  Saito, Yoshihiko⁴  Hou, Jingbo⁵  Suzuki, Nobuaki⁶  Zhang, Shaosong⁷ 

[1] Wakayama Med Univ, Dept Cardiovasc Med, Wakayama 6418510, Japan

[2] Kobe Univ, Div Cardiovasc Med, Grad Sch Med, Kobe, Hyogo 657, Japan

[3] Toyohashi Heart Ctr, Dept Cardiol, Toyohashi, Aichi, Japan

[4] Nara Med Univ, Dept Internal Med 1, Kashihara, Nara 634, Japan

[5] Harbin Med Univ, Dept Cardiol, Key Labs,Affiliated Hosp 2, Educ Minist Myocardial Ischemia Mech & Treatment, Harbin, Peoples R China

[6] Teikyo Univ, Sch Med, Dept Med, Tokyo 173, Japan

[7] Lightlab Imaging St Jude Med, Westford, MA USA

关键词: coronary angiography;    intravascular ultrasound;    optical coherence tomography;   

DOI  :  10.1016/j.jcmg.2013.04.014

来源: Elsevier

【 摘 要 】

OBJECTIVES The aim of this study was to investigate the reliability of frequency domain optical coherence tomography (FD-OCT) for coronary measurements compared with quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS). BACKGROUND Accurate luminal measurement is expected in FD-OCT because this technology offers high resolution and excellent contrast between lumen and vessel wall. METHODS In 5 medical centers, 100 patients with coronary artery disease were prospectively studied by using angiography, FD-OCT, and IVUS. In addition, 5 phantom models of known lumen dimensions (lumen diameter 3.08 mm; lumen area 7.45 mm(2)) were examined using FD-OCT and IVUS. Quantitative image analyses of the coronary arteries and phantom models were performed by an independent core laboratory. RESULTS In the clinical study, the mean minimum lumen diameter measured by QCA was significantly smaller than that measured by FD-OCT (1.81 +/- 0.72 mm vs. 1.91 +/- 0.69 mm; p < 0.001) and the minimum lumen diameter measured by IVUS was significantly greater than that measured by FD-OCT (2.09 +/- 0.60 mm vs. 1.91 +/- 0.69 mm; p < 0.001). The minimum lumen area measured by IVUS was significantly greater than that by FD-OCT (3.68 +/- 2.06 mm(2) vs. 3.27 +/- 2.22 mm(2); p < 0.001), although a significant correlation was observed between the 2 imaging techniques (r = 0.95, p < 0.001; mean difference 0.41 mm(2)). Both FD-OCT and IVUS exhibited good interobserver reproducibility, but the root-mean-squared deviation between measurements was approximately twice as high for the IVUS measurements compared with the FD-OCT measurements (0.32 mm(2) vs. 0.16 mm(2)). In a phantom model, the mean lumen area according to FD-OCT was equal to the actual lumen area of the phantom model, with low SD; IVUS overestimated the lumen area and was less reproducible than FD-OCT (8.03 +/- 0.58 mm(2) vs. 7.45 +/- 0.17 mm(2); p < 0.001). CONCLUSIONS The results of this prospective multicenter study demonstrate that FD-OCT provides accurate and reproducible quantitative measurements of coronary dimensions in the clinical setting. (C) 2013 by the American College of Cardiology Foundation

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