Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties

JOURNAL OF CONTROLLED RELEASE

卷:263

Article; Proceedings Paper

Cai, Kaimin¹  Wang, Andrew Z.^9,10  Yin, Lichen⁸  Cheng, Jianjun^{1,2,3,4,5,6,7,8} 

[1] Univ Illinois, Dept Mat Sci & Engn, 1304 W Green St, Chicago, IL 61801 USA

[2] Univ Illinois, Dept Bioengn, 1304 W Green St, Chicago, IL 61801 USA

[3] Univ Illinois, Dept Chem, 1304 W Green St, Chicago, IL 61801 USA

[4] Univ Illinois, Beckman Inst Adv Sci & Technol, 1304 W Green St, Chicago, IL 61801 USA

[5] Univ Illinois, Micro & Nanotechnol Lab, 1304 W Green St, Chicago, IL 61801 USA

[6] Univ Illinois, Inst Genom Biol, 1304 W Green St, Chicago, IL 61801 USA

[7] Univ Illinois, Mat Res Lab, 1304 W Green St, Chicago, IL 61801 USA

[8] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China

[9] Univ N Carolina, Lineberger Comprehens Canc Ctr, Carolina Ctr Canc Nanotechnol Excellence, Lab Nano & Translat Med, Chapel Hill, NC 27599 USA

[10] Univ N Carolina, Lineberger Comprehens Canc Ctr, Carolina Ctr Canc Nanotechnol Excellence, Dept Radiat Oncol, Chapel Hill, NC 27599 USA

关键词: Nanomedicine;    Drug delivery;    Protein corona;    Intracellular delivery;    Cell-mediated delivery;   

DOI  :  10.1016/j.jconrel.2016.11.034

来源: Elsevier

【 摘 要 】

The past several decades have witnessed the rapid development of nanomedicine (NM) which integrates the advancement of various interdisciplinary areas of science, engineering, andmedicine. While a fewclinical successes of NM greatly change the landscape of disease diagnosis and treatment, there are several areas of NM remaining to be explored. One such area is the complicated interactions between the NM and biological environment post administration, and how such interaction affects the biological performance of NM. Here, we review the recent progresses on this topic and discuss the interaction of NM with microscopic biomolecules, cells, and the macroscopic in vivo environment. The complete profiling of the bio/nanomaterials interface and interaction should have profound impact on the optimization and de novo design of new NM with better in vivo performance. (C) 2017 Elsevier B.V. All rights reserved.

【 授权许可】

Free