Biochemical engineering nerve conduits using peptide amphiphiles

JOURNAL OF CONTROLLED RELEASE

卷:163

Review

Tan, Aaron¹  Rajadas, Jayakumar²  Seifalian, Alexander M.^1,3 

[1] UCL, UCL Div Surg & Intervent Sci, Ctr Nanotechnol & Regenerat Med, London NW3 2QG, England

[2] Stanford Univ, Dept Neurol & Neurol Sci, Sch Med, Biomat & Adv Drug Delivery Lab, Stanford, CA 94305 USA

[3] Royal Free London NHS Fdn Trust Hosp, London, England

关键词: Drug delivery;    Peptide amphiphiles;    Nerve conduit;    Biochemical engineering;    Nerve tissue engineering;   

DOI  :  10.1016/j.jconrel.2012.08.009

来源: Elsevier

【 摘 要 】

Peripheral nerve injury is a debilitating condition. The gold standard for treatment is surgery, requiring an autologous nerve graft. Grafts are harvested from another part of the body (a secondary site) to treat the affected primary area. However, autologous nerve graft harvesting is not without risks, with associated problems including injury to the secondary site. Research into biomaterials has engendered the use of bioartificial nerve conduits as an alternative to autologous nerve grafts. These include synthetic and artificial materials, which can be manufactured into nerve conduits using techniques inspired by nanotechnology. Recent evidence indicates that peptide amphiphiles (PAs) are promising candidates for use as materials for bioengineering nerve conduits. PAs are biocompatible and biodegradable protein-based nanomaterials, capable of self-assembly in aqueous solutions. Their self-assembly system, coupled with their intrinsic capacity for carrying bioactive epitopes for tissue regeneration, form particularly novel attributes for biochemically-engineered materials. Furthermore, PAs can function as biomimetic materials and advanced drug delivery platforms for sustained and controlled release of a plethora of therapeutic agents. Here we review the realm of nerve conduit tissue engineering and the potential for PAs as viable materials in this exciting and rapidly advancing field. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free