ADRIAMYCIN LOADING AND RELEASE CHARACTERISTICS OF ALBUMIN-HEPARIN CONJUGATE MICROSPHERES

JOURNAL OF CONTROLLED RELEASE

卷:29

Article

CREMERS, HFM ; VERRIJK, R ; NOTEBORN, HPJM ; KWON, G ; BAE, YH ; KIM, SW ; FEIJEN, J

关键词: ADRIAMYCIN;    MICROSPHERE;    ION-EXCHANGE;    HYDROGEL;    DRUG DELIVERY;   

DOI  :  10.1016/0168-3659(94)90130-9

来源: Elsevier

【 摘 要 】

Biodegradable ion-exchange microspheres, prepared from a prefabricated conjugate of albumin and heparin were investigated as carriers for adriamycin. The ion-exchange microspheres could be loaded with adriamycin giving payloads up to 33% w/w, depending on the heparin content of the conjugate. In vitro adriamycin release depended on the ionic strength of the release medium. In ion containing media, for instance saline, 90% of the drug was released within 45 min, whereas in non-ionic media, such as distilled water, only 30% was released. Drug release profiles could be modelled by combining ion-exchange kinetics and diffusion controlled drug release models.

【 授权许可】

Free