Plasmonic photothermal therapy increases the tumor mass penetration of HPMA copolymers

JOURNAL OF CONTROLLED RELEASE

卷:166

Article

Gormley, Adam J.^1,2  Larson, Nate^2,3  Banisadr, Afsheen^1,2  Robinson, Ryan^1,2  Frazier, Nick^1,2  Ray, Abhijit^2,3  Ghandehari, Hamidreza^1,2,3 

[1] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

[2] Univ Utah, Nano Inst Utah, Ctr Nanomed, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA

关键词: HPMA copolymers;    Gold nanorods;    Photothermal therapy;    Hyperthermia;    MRI;    Drug delivery;   

DOI  :  10.1016/j.jconrel.2012.12.007

来源: Elsevier

【 摘 要 】

Effective drug delivery to tumors requires both transport through the vasculature and tumor interstitium. Previously, it was shown that gold nanorod (GNR) mediated plasmonic photothermal therapy (PPTT) is capable of increasing the overall accumulation of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers in prostate tumors. In the present study, it is demonstrated that PPTT is also capable of increasing the distribution of these conjugates in tumors. Gadolinium labeled HPMA copolymers were administered to mice bearing prostate tumors immediately before treatment of the right tumor with PPTT. The left tumor served as internal, untreated control. Magnetic resonance imaging (MRI) of both tumors showed that PPTT was capable of improving the tumor mass penetration of HPMA copolymers. Thermal enhancement of delivery, roughly 1.5-fold, to both the tumor center and periphery was observed. Confocal microscopy of fluorescently labeled copolymers corroborates these findings in that PPTT is capable of delivering more HPMA copolymers to the tumor's center and periphery. These results further demonstrate that PPTT is a useful tool to improve the delivery of polymer-drug conjugates. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

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