Macromolecular therapeutics

JOURNAL OF CONTROLLED RELEASE

卷:190

Review

Yang, Jiyuan¹  Kopecek, Jindrich^1,2 

[1] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

关键词: Water-soluble polymers;    Macromolecular therapeutics;    Degradable polymeric carriers;    Drug-free macromolecular therapeutics;    Cancer;    N-(2-hydroxypropyl)methacrylamide;   

DOI  :  10.1016/j.jconrel.2014.04.013

来源: Elsevier

【 摘 要 】

This review covers water-soluble polymer-drug conjugates and macromolecules that possess biological activity without attached low molecular weight drugs. The main design principles of traditional and backbone degradable polymer-drug conjugates as well as the development of a new paradigm in nanomedicines - (low molecular weight) drug-free macromolecular therapeutics are discussed. To address the biological features of cancer, macromolecular therapeutics directed to stem/progenitor cells and the tumor microenvironment are deliberated. Finally, the future perspectives of the field are briefly debated. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

Free