Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization

JOURNAL OF CONTROLLED RELEASE

卷:303

Review

Wang, Ning¹  Chen, Minnan²  Wang, Ting² 

[1] Hefei Univ Technol, Sch Food & Bioengn, 193 Tun Brook Rd, Hefei 230009, Anhui, Peoples R China

[2] Anhui Med Univ, Sch Pharm, 81 Plum Hill Rd, Hefei 230032, Anhui, Peoples R China

关键词: Vaccine adjuvant-delivery system;    Mucosal vaccination;    Pathogen-associated molecular pattern;    Antigen cross-presentation;    Immunoresponse;    Cellular immunity;   

DOI  :  10.1016/j.jconrel.2019.04.025

来源: Elsevier

【 摘 要 】

Liposomes are widely utilized as a carrier to improve therapeutic efficacy of agents thanks to their merits of high loading capacity, targeting delivery, reliable protection of agents, good biocompatibility, versatile structure modification and adjustable characteristics, such as size, surface charge, membrane flexibility and the agent loading mode. In particular, in recent years, through modification with immunopotentiators and targeting molecules, and in combination with innovative immunization devices, liposomes are rapidly developed as a multifunctional vaccine adjuvant-delivery system (VADS) that has a high capability in inducing desired immunoresponses, as they can target immune cells and even cellular organelles, engender lysosome escape, and promote Ag cross-presentation, thus enormously enhancing vaccination efficacy. Moreover, after decades of development, several products developed on liposome VADS have already been authorized for clinical immunization and are showing great advantages over conventional vaccines. This article describes in depth some critical issues relevant to the development of liposomes as a VADS, including principles underlying immunization, physicochemical properties of liposomes as the immunity-influencing factors, functional material modification to enhance immunostimulatory functions, the state-of-the-art liposome VADSs, as well as the marketed vaccines based on a liposome VADS. Therefore, this article provides a comprehensive reference to the development of novel liposome vaccines.

【 授权许可】

Free