Release of anti-restenosis drugs from poly(ethylene oxide)-poly (DL-lactic-co-glycolic acid) nanoparticles

JOURNAL OF CONTROLLED RELEASE

卷:114

Article

Zweers, Miechel L. T. ; Engbers, Gerard H. M. ; Grijpma, Dirk W. ; Feijen, Jan

关键词: restenosis;    rapamycin;    dexamethasone;    biodegradable nanoparticles;   

DOI  :  10.1016/j.jconrel.2006.05.021

来源: Elsevier

【 摘 要 】

Dexamethasone- or rapamycin-loaded nanoparticles based on poly(ethylene oxide) and poly(DL-lactic-co-glycolic acid) block copolymers (PEO-PLGA) were prepared without additional stabilizer using the salting-out method. A fast release of drug in PBS (PH 7.4) at 37 degrees C resulting in 100% release within 5 It was observed for both drugs. The rate of drug release was substantially reduced by treating the particles with gelatin or albumin after drug loading, resulting in a linear drug release in time. It was shown that the rate of drug release is related to the amount of protein associated with the nanoparticles. After gelatin treatment of drug-loaded nanoparticles, sustained release of dexamethasone for 17 days and of rapamycin for 50 days could be achieved. (c) 2006 Elsevier B.V All rights reserved.

【 授权许可】

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