Silk-based stabilization of biomacromolecules

JOURNAL OF CONTROLLED RELEASE

卷:219

Article

Li, Adrian B.¹  Kluge, Jonathan A.²  Guziewicz, Nicholas A.³  Omenetto, Fiorenzo G.²  Kaplan, David L.^1,2 

[1] Tufts Univ, Dept Chem & Biol Engn, Medford, MA 02155 USA

[2] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA

[3] Amgen Inc, Drug Prod Technol, Thousand Oaks, CA 91320 USA

关键词: Silk;    Stabilization;    Recovery;    Biologics;    Mechanisms;    Processing;    Interactions;   

DOI  :  10.1016/j.jconrel.2015.09.037

来源: Elsevier

【 摘 要 】

Silk fibroin is a high molecular weight amphiphilic protein that self-assembles into robust biomaterials with remarkable properties including stabilization of biologicals and tunable release kinetics correlated to processing conditions. Cells, antibiotics, monoclonal antibodies and peptides, among other biologics, have been encapsulated in silk using various processing approaches and material formats. The mechanistic basis for the entrapment and stabilization features, along with insights into the modulation of release of the entrained compounds from silks will be reviewed with a focus on stabilization of bioactive molecules. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free