Nanogels for intracellular delivery of biotherapeutics

JOURNAL OF CONTROLLED RELEASE

卷:259

Review

Li, Dandan¹  van Nostrum, Cornelus F.¹  Mastrobattista, Enrico¹  Vermonden, Tina¹  Hennink, Wim E.¹ 

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, Univ Weg 99, NL-3584 CG Utrecht, Netherlands

关键词: Nanogels;    Intracellular delivery;    Stimuli responsive;    Biotherapeutics;   

DOI  :  10.1016/j.jconrel.2016.12.020

来源: Elsevier

【 摘 要 】

Many biomolecules, such as proteins and genes, are presently used as therapeutics. However, their delivery to target sites inside cells is challenging because of their large molecular size, difficulties to pass cellular membranes and their susceptibility for enzymatic and chemical degradation. Nanogels, three-dimensional networks of hydrophilic polymers, are attractive carrier systems for these biotherapeutics because they protect the biologicals against degradation and, importantly, facilitate cell internalization. Furthermore, the development of responsive nanogel delivery systems has resulted in particles that release their payloads due to a certain physiological trigger inside cells, such as in the cytosol or endocytic compartments. This paper reviews and discusses the use of nanogels, with special emphasis on biologically responsive systems, for intracellular delivery of biotherapeutics. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free