Thermosensitive liposomes for localized delivery and triggered release of chemotherapy

JOURNAL OF CONTROLLED RELEASE

卷:169

Review

Ta, Terence¹  Porter, Tyrone M.² 

[1] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[2] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA

关键词: Drug delivery;    Thermosensitive liposomes;    Thermosensitive polymers;    Chemotherapy;   

DOI  :  10.1016/j.jconrel.2013.03.036

来源: Elsevier

【 摘 要 】

Liposomes are a promising class of nanomedicine with the potential to provide site-specific chemotherapy, thus improving the quality of cancer patient care. First-generation liposomes have emerged as one of the first nanomedicines used clinically for localized delivery of chemotherapy. Second-generation liposomes, i.e. stimuli-responsive liposomes, have the potential to not only provide site-specific chemotherapy, but also triggered drug release and thus greater spatial and temporal control of therapy. Temperature-sensitive liposomes are an especially attractive option, as tumors can be heated in a controlled and predictable manner with external energy sources. Traditional thermosensitive liposomes are composed of lipids that undergo a gel-to-liquid phase transition at several degrees above physiological temperature. More recently, temperature-sensitization of liposomes has been demonstrated with the use of lysolipids and synthetic temperature-sensitive polymers. The design, drug release behavior, and clinical potential of various temperature-sensitive liposomes, as well as the various heating modalities used to trigger release, are discussed in this review. (C) 2013 Elsevier B.V. All rights reserved.

【 授权许可】

Free