Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres - A review

JOURNAL OF CONTROLLED RELEASE

卷:165

Review

Versypt, Ashlee N. Ford^1,2  Pack, Daniel W.^1,3,4  Braatz, Richard D.^1,2 

[1] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[3] Univ Kentucky, Dept Chem & Mat Engn, Lexington, KY 40506 USA

[4] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40506 USA

关键词: Modeling;    Controlled release drug delivery;    PLGA;    Autocatalysis;    Bulk degradation;    Degradable polymer;   

DOI  :  10.1016/j.jconrel.2012.10.015

来源: Elsevier

【 摘 要 】

PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles. (C) 2012 Elsevier B.V. All rights reserved.

【 授权许可】

Free