Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma

JOURNAL OF CONTROLLED RELEASE

卷:223

Article

Cheng, Yu^2,3  Muroski, Megan E.¹  Petit, Dorothee C. M. C.⁴  Mansell, Rhodri⁴  Vemulkar, Tarun⁴  Morshed, Ramin A.³  Han, Yu¹  Balyasnikova, Irina V.¹  Horbinski, Craig M.¹  Huang, Xinlei³  Zhang, Lingjiao³  Cowburn, Russell P.⁴  Lesniak, Maciej S.¹ 

[1] Northwestern Univ, Feinberg Sch Med, 676 N St Clair St,Suite 2210, Chicago, IL 60611 USA

[2] Tongji Univ, Inst Biomed Engn & Nano Sci, Shanghai East Hosp, Sch Med, Shanghai 200092, Peoples R China

[3] Univ Chicago, Brain Tumor Ctr, Chicago, IL 60637 USA

[4] Univ Cambridge, Cavendish Lab, Thin Film Magnetism Grp, JJ Thomson Ave, Cambridge CB3 0HE, England

关键词: Magnetic particles;    Mechanical destruction;    Magnetic field;    Malignant glioma;   

DOI  :  10.1016/j.jconrel.2015.12.028

来源: Elsevier

【 摘 要 】

Magnetic particles that can be precisely controlled under a magnetic field and transduce energy from the applied field open the way for innovative cancer treatment. Although these particles represent an area of active development for drug delivery and magnetic hyperthermia, the in vivo anti-tumor effect under a low-frequency magnetic field using magnetic particles has not yet been demonstrated. To-date, induced cancer cell death via the oscillation of nanoparticles under a low-frequency magnetic field has only been observed in vitro. In this report, we demonstrate the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. The internalized nanomagnets align themselves to the plane of the rotating magnetic field, creating a strong mechanical force which damages the cancer cell structure inducing programmed cell death. In vivo, the magnetic field treatment successfully reduces brain tumor size and increases the survival rate of mice bearing intracranial glioma xenografts, without adverse side effects. This study demonstrates a novel approach of controlling magnetic particles for treating malignant glioma that should be applicable to treat a wide range of cancers. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

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