Chromophores in operative surgery: Current practice and rationalized development

JOURNAL OF CONTROLLED RELEASE

卷:249

Review

Azzopardi, Ernest A.^1,4  Owens, Sian-Eleri^1,2  Murison, Maxwell⁴  Rees, Daniel¹  Sawhney, M. Anne¹  Francis, Lewis W.^1,2  Teixeira, R. Sofia Rodrigues²  Clement, Marc³  Conlan, R. Steven^1,2  Whitaker, Iain S.^1,4 

[1] Swansea Univ, Swansea Univ Med Sch, Singleton Pk Campus, Swansea SA2 8PP, W Glam, Wales

[2] Swansea Univ, Sch Management, Bay Campus, Swansea, W Glam, Wales

[3] Swansea Univ, Inst Life Sci, Enterprise & Innovat Grp, Singleton Campus, Swansea, W Glam, Wales

[4] Morriston Hosp, Welsh Ctr Burns & Plast Surg, Swansea, W Glam, Wales

关键词: Chromophore;    Stain;    Dye;    Pigment;    Contrast agent;    Fluorophore;    Optical adjunct;    Ultraviolet;    Infrared;    Methylene blue;    Patent Blue V;    Bonney's blue;    Indocyanine green;    Porphyrin;    Melanin;    Triarylmethane;    Triphenylmethane;    Azo derivative;    Phenothiazine;    surgery;    optical;    lymphadenectomy;    sentinel lymph node biopsy;   

DOI  :  10.1016/j.jconrel.2016.12.044

来源: Elsevier

【 摘 要 】

Background: Chromophore-containing molecules feature extensively in surgical practice, with synthetic dyes gaining popularity over endogenous optical adjuncts. New applications for chromophores in diagnostics and operative treatment exploit unique chemical structures suited for illuminating target tissues beyond the visual spectrum, ranging from ultraviolet (UV) to near-infrared (NIR). This review outlines the rationale for surgical chromophore application, the weaknesses and risks in each class of these compounds, and areas of foreseeable potential for employment of specialized contrast agents. Method: An English-language literature search applied the following Boolean Search String: dye OR Lake OR Stain OR chromophore AND tox$ OR terato* OR carcino$ OR Allerg$ OR surg$ OR clinic using EMBASE, PUBMED, PUBMED central and OVIDSp, with back-referencing through Web of Knowledge(TM). Results: Based on the primary literature, this study proposes a surgically relevant classification system of chromophores in current use, which facilitates risk/benefit consideration for the surgeon who employs them, and which facilitates clinically oriented development. Conclusions: The next stage of development for optically active surgical adjuncts must address practical constraints whilst minimizing risks of adverse effects. Exploiting the technology's full potential also requires improvements in the usefulness of imagery equipment. (C) 2016 Published by Elsevier B.V.

【 授权许可】

Free