Polymeric materials for embolic and chemoembolic applications

JOURNAL OF CONTROLLED RELEASE

卷:240

Article

Poursaid, Azadeh^1,2  Jensen, Mark Martin^1,2  Huo, Eugene³  Ghandehari, Hamidreza^1,2,4 

[1] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

[2] Univ Utah, Nano Inst Utah, Ctr Nanomed, Salt Lake City, UT 84112 USA

[3] Vet Affairs Hosp, Salt Lake City, UT 84108 USA

[4] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA

关键词: Embolics;    Polymers;    Drug eluting beads;    Hepatocellular carcinoma;    Arteriovenous malformations;    Uterine fibroids;   

DOI  :  10.1016/j.jconrel.2016.02.033

来源: Elsevier

【 摘 要 】

Percutaneous transcatheter embolization procedures involve the selective occlusion of blood vessels. Occlusive agents, referred to as embolics, vary in material characteristics including chemical composition, mechanical properties, and the ability to concurrently deliver drugs. Commercially available polymeric embolics range from gelatin foam to synthetic polymers such as poly(vinyl alcohol). Current systems under investigation include tunable, bioresorbable microspheres composed of chitosan or poly(ethylene glycol) derivatives, in situ gelling liquid embolics with improved safety profiles, and radiopaque embolics that are trackable in vivo. This article reviews commercially available materials used for embolization as well as polymeric materials that are under investigation. (C) 2016 Elsevier B.V. All rights reserved.

【 授权许可】

Free