Immediate detachment of microneedles by interfacial fracture for sustained delivery of a contraceptive hormone in the skin

JOURNAL OF CONTROLLED RELEASE

卷:337

Article

Lee, Yunki¹  Li, Wei^1,4  Tang, Jie^2,3  Schwendeman, Steven P.^2,3  Prausnitz, Mark R.¹ 

[1] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA

[2] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA

[4] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China

关键词: Microneedle patch;    Transdermal drug delivery;    Long-acting contraception;    Contraceptive hormone;    Immediate needle detachment;    Porous patch backing;   

DOI  :  10.1016/j.jconrel.2021.08.012

来源: Elsevier

【 摘 要 】

Despite their high efficacy and safety, long-acting contraceptive methods are underutilized among women in some settings because they usually require injection or implantation by healthcare personnel. Here, we report a self-administrable microneedle (MN) patch for the rapid administration of a sustained-release contraceptive hormone delivery system into the skin that increases the simplicity and reliability of the MN delivery. We developed an immediate microneedle detachment system using a porous patch backing that has sufficient strength during MN insertion into skin under compression, but enables immediate detachment (< 1 s) of the MNs due to fracture at the MN - backing interface upon patch removal under tension from the skin surface. After patch application, the removed patch produced no biohazardous sharps waste, and was designed to achieve long-acting contraception by formulating poly(lactic-co-glycolic acid) MNs to slowly release the contraceptive hor -mone levonorgestrel for up to 1 month. Our combined strategy using immediate MN detachment in the skin and sustained drug delivery from the MNs could facilitate greater access to long-acting contraception by providing a simple and convenient option for self-administered, long-acting contraception.

【 授权许可】

Free