Allogeneic mesenchymal stem cell sheet therapy: A new frontier in drug delivery systems

JOURNAL OF CONTROLLED RELEASE

卷:330

Article

Kim, Kyungsook¹  Bou-Ghannam, Sophia^1,2  Kameishi, Sumako¹  Oka, Masatoshi¹  Grainger, David W.^1,2  Okano, Teruo^1,3 

[1] Univ Utah, Cell Sheet Tissue Engn Ctr CSTEC, Dept Pharmaceut & Pharmaceut Chem, Hlth Sci, 30 South 2000 East, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Biomed Engn, 36 South,Wasatch Dr, Salt Lake City, UT 84112 USA

[3] Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan

关键词: Clinical use;    Regenerative medicine;    Tissue engineering;    Bioactive drugs;    Biologic;   

DOI  :  10.1016/j.jconrel.2020.12.028

来源: Elsevier

【 摘 要 】

The evolution of drug discovery exploded in the early 20th century with the advent of critical scientific advancements in organic chemistry, chemical analysis, and purification. Early drug generations focused largely on symptom control and pain management, effective targets for small-molecule drugs. Recently, the attention in drug discovery has shifted to pursuit of radical cures. Cell therapy presents the ideal attributes of a promising new drug, targeting specific tissues based on chemotactic cues and modulating secretion of instructive regenerative molecules in response to dynamic signaling from disease environments. To actuate the therapeutic potential of cell therapy toward worldwide clinical use, cell delivery methods that can effectively localize and engraft mesenchymal stem cells (MSCs) with high disease-site fidelity and enable dynamic MSC bioactive function are paramount. In this review, we discuss the evolution of cell therapies with a focus on stem cell advantages, as well as the limitations to these therapies. This review aims to introduce cell sheet technology as a breakthrough cell therapy with demonstrated therapeutic success across indications for heart, liver, and kidney tissue regeneration. Opportunities and anticipated clinical impacts of cell sheet technology using MSCs are discussed.

【 授权许可】

Free