Computational study of blood flow in microchannels

JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS

卷:292

Article

Kim, Jeongho¹  Antaki, James F.²  Massoudi, Mehrdad³ 

[1] Kyung Hee Univ, Dept Mech Engn, Yongin 446701, Kyunggi Do, South Korea

[2] Carnegie Mellon Univ, Dept Biomed Engn, Pittsburgh, PA 15213 USA

[3] US DOE, Natl Energy Technol Lab, Pittsburgh, PA 15236 USA

关键词: Blood flow;    Two-phase flow;    Mixture theory;    Shear-thinning viscosity;    Sudden expansion;    Microchannels;   

DOI  :  10.1016/j.cam.2015.06.017

来源: Elsevier

【 摘 要 】

Using the Theory of Interacting Continua (Mixture Theory), blood is modeled as a two-component mixture, namely, plasma and red blood cells (RBCs). The plasma is assumed to behave as a Newtonian fluid and the RBCs are modeled as a suspension of rigid spherical particles with a viscosity dependent on the shear-rate and the hematocrit. The drag and lift forces are implemented through RBC-plasma interaction forces. We solve the governing equations using the OpenFOAM, an open source CFD code for two phase flow simulations. The two-phase simulations predict RBC depletion in the corner of a sudden expansion channel. The RBC depletion length is found to increase with decreasing the flow rate and the hematocrit. There is a qualitatively good agreement between the simulation results and the experimental data. Published by Elsevier B.V.

【 授权许可】

Free