Immunologic cross-reactivity between respiratory chemical sensitizers: Reactive dyes and cyanuric chloride

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:102

Article

Jones, M ; Graham, C ; Taylor, AN ; Sarlo, K ; Hoyle, V ; Karol, MH

关键词: cyanuric chloride;    reactive dyes;    sensitizers;    IgE antibody;   

DOI  :  10.1016/S0091-6749(98)70025-9

来源: Elsevier

【 摘 要 】

Background: CyCl is a low molecular weight reactive chemical used as an intermediate in the production of plastics, herbicides, pharmaceuticals, and fiber-reactive dyes. It is a potent inducer of specific IgE antibody: The CyCl functionality; is a structural component of monochlorotriazine and dichlorotriazine dyes. Objective: We have investigated the immunologic cross-reactivity between cyanuric chloride (CyCl) and reactive dyes and it was hypothesized that this moiety might be a dye epitope and that it might stimulate an allergic antibody response in dye-exposed workers. Methods: To test this hypothesis, we have used sera with IgE antibodies to CyCl and also sera from dye-exposed workers who have ICE antibodies to Procion Orange MX2R, an azo dye containing the dichlorotriazine group. As a control group we have used dye-exposed workers with IgE antibody to Remazol Black B, a diazo dye containing the vinyl sulfone-reactive group. Results: Using RAST and RAST inhibitions, we identified negligible cross-reactivity between CyCl and dichlorotriazine dye. Conclusion: The results of this study imply that the allergenic moiety on the dye residue resides in the chromophore rather than in the common structural component of CyCl and dichlolotriazine dyes.

【 授权许可】

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