Does higher body mass index contribute to worse asthma control in an urban population?

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:124

Article

Clerisme-Beaty, Emmanuelle M.¹  Karam, Sabine³  Rand, Cynthia¹  Patino, Cecilia M.⁴  Bilderback, Andrew¹  Riekert, Kristin A.¹  Okelo, Sande O.²  Diette, Gregory B.¹ 

[1] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[2] Johns Hopkins Univ, Dept Pediat, Baltimore, MD USA

[3] Albert Einstein Coll Med, Dept Med, New York, NY USA

[4] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

关键词: Asthma;    asthma control;    obesity;    overweight;    body mass index;    inner city;    asthma communication control instrument;    ACCI;    African American;   

DOI  :  10.1016/j.jaci.2009.05.034

来源: Elsevier

【 摘 要 】

Background: Epidemiologic findings support a positive association between asthma and obesity. Objective: Determine whether obesity or increasing level of body mass index (BMI) are associated with worse asthma control in an ethnically diverse urban population. Methods: C ross-sectional assessment of asthma control was performed in patients with asthma recruited from primary care offices by using 4 different validated asthma control questionnaires: the Asthma Control and Communication Instrument (ACCI), the Asthma Control Test (ACT), the Asthma Control Questionnaire (ACQ), and the Asthma Therapy Assessment Questionnaire (ATAQ). Multiple linear regression analysis was performed to evaluate the association between obesity and increasing BMI level and asthma control. Results: Of 292 subjects with a mean age of 47 years, the majority were women (82%) and African American (67%). There was a high prevalence of obesity with 63%, with only 15% normal weight. The mean score from all 4 questionnaires showed an average suboptimal asthma control (mean score/maximum possible score): ACCI (8.3/19), ACT (15.4/25), ACQ (2.1/6), and ATAQ (1.3/4). Regression analysis showed no association between obesity or increasing BMI level and asthma control using all 4 questionnaires. This finding persisted even after adjusting for FEV1, smoking status, race, sex, selected comorbid illnesses, and long-term asthma controller use. Conclusion: Using 4 validated asthma control questionnaires, we failed to find an association between obesity and asthma control in an urban population with asthma. Weight loss may not be an appropriate strategy to improve asthma control in this population. (J Allergy Clin Immunol 2009;124:207-12.)

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