Viral respiratory tract infections and asthma: The course ahead

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:125

Article

Rosenthal, Louis A.^1,2  Avila, Pedro C.³  Heymann, Peter W.⁴  Martin, Richard J.⁵  Miller, E. Kathryn⁶  Papadopoulos, Nikolaos G.⁸  Peebles, R. Stokes, Jr.⁷  Gern, James E.^1,2 

[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI 53792 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI 53792 USA

[3] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Univ Virginia Hlth Syst, Dept Pediat, Charlottesville, VA USA

[5] Natl Jewish Hlth, Dept Med, Denver, CO USA

[6] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[7] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA

[8] Univ Athens, Dept Allergy, Pediat Clin 2, GR-10679 Athens, Greece

关键词: Viral respiratory tract infections;    asthma;    wheezing;    asthma onset;    asthma exacerbations;    respiratory tract viruses;    rhinovirus;    respiratory syncytial virus;    allergy;   

DOI  :  10.1016/j.jaci.2010.04.002

来源: Elsevier

【 摘 要 】

Inquiries into the relationships between viral respiratory tract illnesses and the inception and exacerbation of asthma are being facilitated by recent advances in research approaches and technology. In this article we identify important knowledge gaps and future research questions, and we discuss how new investigational tools, including improved respiratory tract virus detection techniques, will permit current and future researchers to define these relationships and the host, virus, developmental, and environmental mechanisms that regulate them. A better understanding of these processes should facilitate the development of improved strategies for the prevention and treatment of virus-induced wheezing illnesses and asthma exacerbations and, possibly, the ultimate goal of discovering effective approaches for the primary prevention of asthma. (J Allergy Clin Immunol 2010;125:1212-7.)

【 授权许可】

Free