Mechanisms underlying helper T-cell plasticity: Implications for immune-mediated disease

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:131

Article

Hirahara, Kiyoshi¹  Poholek, Amanda¹  Vahedi, Golnaz¹  Laurence, Arian¹  Kanno, Yuka¹  Milner, Joshua D.²  O'Shea, John J.¹ 

[1] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA

[2] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA

关键词: T-cell plasticity;    asthma;    allergic disease;    epigenetics;    histone modification;    therapy;   

DOI  :  10.1016/j.jaci.2013.03.015

来源: Elsevier

【 摘 要 】

CD4 helper T cells are critical for proper immune cell homeostasis and host defense but are also major contributors to immune and inflammatory disease. Arising from a simple biphasic model of differentiation (ie, T(H)1 and T(H)2 cells). A bewildering number of fates seem possible for helper T cells. To what extent different helper cell subsets maintain their characteristic gene expression profiles or exhibit functional plasticity is a hotly debated topic. In this review we will discuss how the expression of signature cytokines'' and master regulator'' transcription factors do not neatly conform to a simple helper T-cell paradigm. Although this might seem confusing, the good news is that the newly recognized complexity fits better with our understanding of immunopathogenesis. Finally, we will discuss factors, including epigenetic regulation and metabolic alterations, that contribute to helper cell specificity and plasticity.

【 授权许可】

Free