Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:135

Article

Westman, Marit^1,3  Lupinek, Christian⁴  Bousquet, Jean⁵  Andersson, Niklas²  Pahr, Sandra⁴  Baar, Alexandra⁴  Bergstrom, Anna²  Holmstrom, Mats^1,3  Stjarne, Par^1,3  Carlsen, Karin C. Lodrup⁶  Carlsen, Kaj-Hakon⁶  Anto, Josep M.^7,8  Valenta, Rudolf⁴  van Hage, Marianne^9,10  Wickman, Magnus^2,11 

[1] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Ear Nose & Throat Dis, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Inst Environm Med, SE-17177 Stockholm, Sweden

[3] Karolinska Univ Hosp, Dept Ear Nose & Throat Dis, Stockholm, Sweden

[4] Med Univ Vienna, Ctr Pathophysiol Infectiol & Immunol, Div Immunopathol, Dept Pathophysiol & Allergy Res, Vienna, Austria

[5] Univ Hosp Montpellier, Hop Arnaud de Villeneuve, INSERM 1018, Villejuif, France

[6] Univ Oslo, Oslo Univ Hosp, Dept Pediat, N-0316 Oslo, Norway

[7] Univ Pompeu Fabra, Barcelona, Spain

[8] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[9] Karolinska Inst, Dept Med Solna, Clin Immunol & Allergy Unit, SE-17177 Stockholm, Sweden

[10] Univ Hosp, Stockholm, Sweden

[11] Sachs Childrens Hosp, Stockholm, Sweden

关键词: Allergen components;    allergic rhinitis;    oral allergy syndrome;    BAMSE;    birch pollen;    cohort;    cross-reactivity;    IgE;    MeDALL;    microarray;   

DOI  :  10.1016/j.jaci.2014.10.042

来源: Elsevier

【 摘 要 】

Background: Component-resolved diagnosis might improve the prediction of future allergy in young children. Objective: We sought to investigate the association between IgE reactivity to the pathogenesis-related class 10 (PR-10) protein family and allergic rhinitis to birch pollen (AR(bp)) from early childhood up to age 16 years. Method: Questionnaire data and sera obtained at 4, 8, and 16 years of age from the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic (BAMSE) study birth cohort were used. Sera from 764 children were analyzed for IgE reactivity to 9 PR-10 allergen proteins at the 3 time points by using an allergen chip based on ISAC technology. ARbp was defined as upper airway symptoms during birch pollen exposure. Results: IgE reactivity to Bet v 1 was found in 12%, 17%, and 25% of children at 4, 8, and 16 years of age. IgE reactivity of PR-10 proteins showed a hierarchic intrarelationship: Bet v 1 > Mal d 1 > Cor a 1.04 > Ara h 8 > Pru p 1 > Aln g 1 > Api g 1 > Act d 8 > Gly m 4. There was an increased risk of incidence and persistence of ARbp up to age 16 years with increasing levels of Bet v 1-specific IgE or increasing numbers of IgE-reactive PR-10 proteins at 4 years. Children with severe ARbp at age 16 years had higher levels of Bet v 1-specific IgE at age 4 years compared with children with mild symptoms. Conclusion: ARbp at age 16 years can be predicted by analysis of IgE reactivity to PR-10 proteins in early childhood.

【 授权许可】

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