Work Group report: Oral food challenge testing

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:123

Review

Nowak-Wegrzyn, Anna²  Assa'ad, Amal H.¹  Bahna, Sami L.³  Bock, S. Allan⁴  Sicherer, Scott H.²  Teuber, Suzanne S.⁵ 

[1] Childrens Hosp, Div Allergy & Immunol, Med Ctr, Cincinnati, OH 45229 USA

[2] Mt Sinai Sch Med, Jaffe Food Allergy Inst, New York, NY USA

[3] Louisiana State Univ, Hlth Sci Ctr, Shreveport, LA 71105 USA

[4] Natl Jewish Hlth & Univ Colorado, Hlth Sci Ctr, Denver, CO USA

[5] Univ Calif Davis, Sch Med, Davis, CA 95616 USA

关键词: Oral food challenge;    food allergy;    food allergens;    anaphylaxis;    food additives;    single-blind;    placebo-controlled oral food challenge;    double-blind;    placebo-controlled oral food challenge;    skin prick test;    IgE;    food protein-induced enterocolitis syndrome;    peanut;    cow's milk;    milk;    egg;    wheat;    tree nuts;   

DOI  :  10.1016/j.jaci.2009.03.042

来源: Elsevier

【 摘 要 】

Oral food challenges are procedures conducted by allergists/immunologists to make an accurate diagnosis of immediate, and occasionally delayed, adverse reactions to foods. The timing of the challenge is carefully chosen based on the individual patient history and the results of skin prick tests and food specific serum IgE values. The type of the challenge is determined by the history, the age of the patient, and the likelihood of encountering subjective reactions. The food challenge requires preparation of the patient for the procedure and preparation of the office for the organized conduct of the challenge, for a careful assessment of the symptoms and signs and the treatment of reactions. The starting dose, the escalation of the dosing, and the intervals between doses are determined based on experience and the patient's history. The interpretation of the results of the challenge and arragements for follow-up after a challenge are important. A negative oral food challenge result allows introduction of the food into the diet, whereas a positive oral food challenge result provides a sound basis for continued avoidance of the food. (J Allergy Clin Immunol 2009;123:S365-83.)

【 授权许可】

Free