Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:131

Article

Donohue, Kathleen M.¹  Hoffman, Eric A.²  Baumhauer, Heather²  Guo, Junfeng²  Ahmed, Firas S.¹  Lovasi, Gina S.¹  Jacobs, David R., Jr.³  Enright, Paul⁴  Barr, R. Graham¹ 

[1] Columbia Univ, New York, NY 10032 USA

[2] Univ Iowa, Iowa City, IA USA

[3] Univ Minnesota, Minneapolis, MN USA

[4] Univ Arizona, Tucson, AZ USA

关键词: Airway remodeling;    airway structure;    asthma;    emphysema;    epidemiology;   

DOI  :  10.1016/j.jaci.2012.11.036

来源: Elsevier

【 摘 要 】

Background: The potential consequences of asthma in childhood and young adulthood on lung structure in older adults have not been studied in a large, population-based cohort. Objective: The authors hypothesized that a history of asthma onset in childhood (age 18 years or before) or young adulthood (age 19-45 years) was associated with altered lung structure on computed tomography in later life. Methods: The Multi-Ethnic Study of Atherosclerosis Lung Study recruited 3965 participants and assessed asthma history by using standardized questionnaires, guideline-based spirometry, and segmental airway dimensions and percentage of low attenuation area (%LAA) on computed tomographic scans. Results: Asthma with onset in childhood and young adulthood was associated with large decrements in FEV1 among participants with a mean age of 66 years (-365 mL and -343 mL, respectively; P<.001). Asthma with onset in childhood and young adulthood was associated with increased mean airway wall thickness standardized to an internal perimeter of 10 mm (0.1 mm, P<.001 for both), predominantly from narrower segmental airway lumens (-0.39 mm and -0.34 mm, respectively; P<.001). Asthma with onset in childhood and young adulthood also was associated with a greater %LAA (1.69% and 4.30%, respectively; P<.001). Findings were similar among never smokers, except that differential %LAA in childhood-onset asthma were not seen in them. Conclusion: Asthma with onset in childhood or young adulthood was associated with reduced lung function, narrower airways, and among asthmatic patients who smoked, greater %LAA in later life. (J Allergy Clin Immunol 2013;131:361-8.)

【 授权许可】

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