Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:134

Article

Siliciano, Janet D.¹  Siliciano, Robert F.^1,2 

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

关键词: HIV;    latency;    eradication;    reservoir;    cure;    stem cell transplantation;    antiretroviral therapy;   

DOI  :  10.1016/j.jaci.2014.05.026

来源: Elsevier

【 摘 要 】

HIV-1 infection can now be readily controlled with combination antiretroviral therapy. However, the virus persists indefinitely in a stable latent reservoir in resting CD4(+) T cells. This reservoir generally prevents cure of the infection with combination antiretroviral therapy alone. However, several recent cases of potential HIV-1 cure have generated renewed optimism. Here we review these cases and consider new developments in our understanding of the latent reservoir. In addition, we consider clinical aspects of curative strategies to provide a more realistic picture of what a generally applicable cure for HIV-1 infection is likely to entail.

【 授权许可】

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