Vitamin D insufficiency is associated with challenge-proven food allergy in infants

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:131

Article

Allen, Katrina J.^1,2,3  Koplin, Jennifer J.^1,2  Ponsonby, Anne-Louise^1,2  Gurrin, Lyle C.^1,4  Wake, Melissa^1,2,5  Vuillermin, Peter^1,6,7  Martin, Pamela¹  Matheson, Melanie⁴  Lowe, Adrian^1,4  Robinson, Marnie³  Tey, Dean³  Osborne, Nicholas J.^1,2,4,8  Thanh Dang¹  Tan, Hern-Tze Tina¹  Thiele, Leone¹  Anderson, Deborah¹  Czech, Helen¹  Sanjeevan, Jeeva¹  Zurzolo, Giovanni¹  Dwyer, Terence¹  Tang, Mimi L. K.^1,2,3  Hill, David¹  Dharmage, Shyamali C.^1,4 

[1] Murdoch Childrens Res Inst, Parkville, Vic, Australia

[2] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia

[3] Royal Childrens Hosp, Dept Allergy & Immunol, Parkville, Vic 3052, Australia

[4] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Parkville, Vic 3052, Australia

[5] Royal Childrens Hosp, Ctr Community Child Hlth, Parkville, Vic 3052, Australia

[6] Barwon Hlth, Child Hlth Res Unit, Geelong, Vic, Australia

[7] Deakin Univ, Geelong, Vic 3217, Australia

[8] Univ Exeter, Peninsula Coll Med & Dent, European Ctr Environm & Human Hlth, Exeter EX4 4QJ, Devon, England

关键词: Vitamin D;    food allergy;    peanut allergy;    egg allergy;    population;    oral food challenge;    eczema;    epigenetic;   

DOI  :  10.1016/j.jaci.2013.01.017

来源: Elsevier

【 摘 要 】

Background: Epidemiological evidence has shown that pediatric food allergy is more prevalent in regions further from the equator, suggesting that vitamin D insufficiency may play a role in this disease. Objective: To investigate the role of vitamin D status in infantile food allergy. Methods: A population sample of 5276 one-year-old infants underwent skin prick testing to peanut, egg, sesame, and cow's milk or shrimp. All those with a detectable wheal and a random sample of participants with negative skin prick test results attended a hospital-based food challenge clinic. Blood samples were available for 577 infants (344 with challenge-proven food allergy, 74 sensitized but tolerant to food challenge, 159 negative on skin prick test and food challenge). Serum 25-hydroxyvitamin D levels were measured by using liquid chromatography tandem mass spectrometry. Associations between serum 25-hydroxyvitamin D and food allergy were examined by using multiple logistic regression, adjusting for potential risk and confounding factors. Results: Infants of Australian-born parents, but not of parents born overseas, with vitamin D insufficiency (<= 50 nmol/L) were more likely to be peanut (adjusted odds ratio [aOR], 11.51; 95% CI, 2.01-65.79; P = .006) and/or egg (aOR, 3.79; 95% CI, 1.1912.08; P = .025) allergic than were those with adequate vitamin D levels independent of eczema status. Among those with Australian-born parents, infants with vitamin D insufficiency were more likely to have multiple food allergies (>= 2) rather than a single food allergy (aOR, 10.48; 95% CI, 1.60-68.61 vs aOR, 1.82; 95% CI, 0.38-8.77, respectively). Conclusions: These results provide the first direct evidence that vitamin D sufficiency may be an important protective factor for food allergy in the first year of life. (J Allergy Clin Immunol 2013; 131:1109-16.)

【 授权许可】

Free