Quantifying asthma symptoms in adults: The Lara Asthma Symptom Scale

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:120

Article

Wood, Pamela Runge¹  Smith, Brad⁴  O'Donnell, Louise^1,2  Galbreath, Autumn Dawn^3,5  Lara, Marielena⁶  Forkner, Emma⁴  Peters, Jay I.³ 

[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX 78229 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA

[4] Altarum Inst, San Antonio, TX USA

[5] Texas Transplant Inst, San Antonio, TX USA

[6] Rand Hlth, Santa Monica, CA USA

关键词: health status indicators;    asthma symptoms;    quality of life;    Hispanic Americans;    psychometrics;    severity of illness index;    questionnaire;    asthma;    outcome assessment;   

DOI  :  10.1016/j.jaci.2007.09.025

来源: Elsevier

【 摘 要 】

Background: Accurate assessment of asthma symptoms is critical in research and clinical settings. A multidimensional asthma control questionnaire could provide more accurate information about asthma symptoms than global assessments, which often overestimate asthma control. Objective: We sought to evaluate the efficacy of the Lara Asthma Symptom Scale (LASS) in adults with persistent asthma. Methods: Participants were 18 to 64 years of age with persistent asthma. Data were collected at baseline, 6 months, and 12 months. We described the construct and predictive validity of the LASS by comparing it with measures of pulmonary function (FEV1), asthma-specific quality of life (Juniper's Asthma Quality of Life Questionnaire [AQLQ]), and health care use (emergency department [ED] visits and hospitalizations). Results: Three hundred eighty-three participants provided baseline data. The LASS had high internal consistency reliability (Cronbach alpha = .84). LASS scores correlated significantly with baseline measures of FEV1 (-0.20, P = .0002), AQLQ (-0.68, P < .0001), ED visits (0.17, P = .002), and hospitalizations (0.15, P = .008). Baseline LASS scores were associated significantly with ED visits (P = .03) and hospitalizations (P = .04) over the subsequent 12 months. Change in LASS scores over time correlated significantly with changes in FEV1 (-0.22, P = .001) and AQLQ (-0.70, P < .001). Conclusions: The LASS demonstrated good internal consistency, excellent validity based on concurrent criterion validity and longitudinal predictive validity, and good discriminatory properties in a heterogeneous sample of adults with persistent asthma. Clinical implications: This study validates a simple multidimensional asthma questionnaire as a clinical tool in the assessment of asthma control in adults.

【 授权许可】

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