Mechanisms of food allergy

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:141

Article

Sampson, Hugh A.¹  O'Mahony, Liam²  Burks, A. Wesley³  Plaut, Marshall⁴  Lack, Gideon^5,6  Akdis, Cezmi A.² 

[1] Icahn Sch Med Mt Sinai, Dept Pediat, Elliot & Roslyn Jaffe Food Allergy Inst, Div Allergy & Immunol,Kravis Childrens Hosp, New York, NY 10029 USA

[2] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[3] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA

[4] NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA

[5] Kings Coll London, Dept Paediat Allergy, Div Asthma Allergy & Lung Biol, London, England

[6] St Thomas NHS Fdn Trust, London, England

关键词: Food allergy;    sensitization;    tolerance;    desensitization;    sustained unresponsiveness;    remission;    allergen immunotherapy;    microbiota;   

DOI  :  10.1016/j.jaci.2017.11.005

来源: Elsevier

【 摘 要 】

Although oral tolerance is the normal physiologic response to ingested antigens, a breakdown in this process appears to have occurred in the past 2 decades, leading to an increasing prevalence of sensitization to food allergens. Over the past decade, basic research has intensified in an attempt to better understand the mechanisms leading to sensitization and disease versus desensitization and short- and long-term tolerance. In this review we assess various factors that can influence tissue and immune responses to food antigens, the current understanding of immune tolerance development, the role of the gastrointestinal microbiota, and current knowledge regarding immunologic mechanisms involved in desensitization and sustained unresponsiveness, although perhaps the latter is more appropriately termed remission.

【 授权许可】

Free