Randomized placebo-controlled trial of hen's egg consumption for primary prevention in infants

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:139

Article

Bellach, Johanna¹  Schwarz, Veronika¹  Ahrens, Birgit¹  Trendelenburg, Valerie¹  Aksuenger, Oezlem¹  Kalb, Birgit¹  Niggemann, Bodo¹  Keil, Thomas²  Beyer, Kirsten^1,3 

[1] Charite, Dept Paediat Pneumol & Immunol, Berlin, Germany

[2] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany

[3] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

关键词: Food allergy;    hen's egg allergy;    allergy prevention;    atopic eczema;    oral tolerance;    randomized controlled trial;    complementary feeding;   

DOI  :  10.1016/j.jaci.2016.06.045

来源: Elsevier

【 摘 要 】

Background: Hen's egg is the most common cause of food allergy in early childhood. Objective: We investigated the efficacy and safety of early hen's egg introduction at age 4 to 6 months to prevent hen's egg allergy in the general population. Methods: This randomized, placebo-controlled trial included 4to 6-month-old infants who were not sensitized against hen's egg, as determined based on specific serum antibodies (IgE). These infants were randomized to receive either verum (egg white powder) or placebo (rice powder) added to the first weaning food 3 times a week under a concurrent egg-free diet from age 4 to 6 until 12 months. The primary outcome was sensitization to hen's egg (increased specific serum IgE levels) by age 12 months. Hen's egg allergy (secondary outcome) was confirmed by double-blind, placebo-controlled food challenges. Results: Among 406 screened infants, 23 (5.7%) had hen's egg-specific IgE before randomization. Seventeen of 23 underwent subsequent double-blind, placebo-controlled food challenges, and 16 were confirmed as allergic, including 11 with anaphylactic reactions. Of the 383 nonsensitized infants (56.7% male), 184 were randomized to verum and 199 to placebo. At 12 months of age, 5.6% of the children in the verum group were hen's egg sensitized versus 2.6% in the placebo group (primary outcome; relative risk, 2.20; 95% CI, 0.68-7.14; P = .24), and 2.1% were confirmed to have hen's egg allergy versus 0.6% in the placebo group (relative risk, 3.30; 95% CI, 0.35-31.32; P = .35). Conclusion: We found no evidence that consumption of hen's egg starting at 4 to 6 months of age prevents hen's egg sensitization or allergy. In contrast, it might result in frequent allergic reactions in the community considering that many 4-to 6-month-old infants were already allergic to hen's egg.

【 授权许可】

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