The role of lymphocytes in allergic disease

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:105

Review

Romagnani, S

关键词: T(H)1/T(H)2 cells;    atopy;    cytokines;    chemokines;    hygiene hypothesis;    oligodeoxynucleotides;    allergy;    asthma;    allergic rhinitis;   

DOI  :  10.1067/mai.2000.104575

来源: Elsevier

【 摘 要 】

In the last few years strong evidence has accumulated to suggest that allergen-reactive type-2 T helper (T(H)2) cells play an important role in the induction and maintenance of the allergic inflammatory cascade, First, cytokines and chemokines produced by T(H)2 cells (CM-CSF, IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, macrophage-derived chemokine) and those produced bg other cell types in response to T(H)2 cytokines or as a reaction to T(H)2-related tissue damage (eotaxin, transforming growth factor-beta, IL-11) account for most pathophysiologic aspects of allergic disorders (production of IgE antibodies; recruitment or activation of mast cells, basophils, and eosinophils; mucus hypersecretion; subepithelial fibrosis; and tissue remodeling). The T(H)2 hypothesis may also explain the complex genetic background responsible fur allergic disorders. Several genes are involved in the development and regulation of T(H)2 cells and may provide the reason why the prevalence of atopic allergy is increasing in Western countries. Indeed, a dramatic change has occurred in the last several decades in the microbial environment of children, thus probably altering the balance between T(H)1 and T(H)2 responses to innocuous antigens (allergens) in favor of T(H)2 responses. Finally, the T(H)2 hypothesis offers exciting opportunities for the development of novel immunotherapeutic strategics targeted to address allergen-specific T(H)2 cells or T(H)2-derived effector molecules in atopic individuals.

【 授权许可】

Free