The role of lectins in allergic sensitization and allergic disease

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:132

Article

Salazar, Fabian¹  Sewell, Herb F.¹  Shakib, Farouk¹  Ghaemmaghami, Amir M.¹ 

[1] Univ Nottingham, Fac Med & Hlth Sci, Nottingham NG7 2UH, England

关键词: C-type lectin receptor;    lectin;    glycosylation;    allergen type-I hypersensitivity;    asthma;    house dust mite;    mannose receptor;    DC-SIGN;    Toll-like receptor;    dendritic cells;    galactins;   

DOI  :  10.1016/j.jaci.2013.02.001

来源: Elsevier

【 摘 要 】

Allergic diseases are a global public health issue affecting millions of persons around the world. However, full understanding of the molecular basis of this group of chronic inflammatory disorders remains rather elusive. Recently, the role of carbohydrates on allergens and their counter structures on antigen-presenting cells (lectins) have been highlighted as crucial factors in allergen sensitization, which culminates in TH2 cell differentiation and the production of deleterious specific IgE antibodies. Here we review recent progress on the role of different lectins in patients with type I hypersensitivity or allergy, their interplay with other determinants of allergenicity, and ways of developing therapeutic modalities against newly identified targets.

【 授权许可】

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