Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:136

Article

Wheatley, Lisa M.¹  Plaut, Marshall¹  Schwaninger, Julie M.¹  Banerji, Aleena²  Castells, Mariana³  Finkelman, Fred D.^4,5  Gleich, Gerald J.^6,7  Guttman-Yassky, Emma^8,9  Mallal, Simon A. K.^10,11  Naisbitt, Dean J.¹²  Ostrov, David A.¹³  Phillips, Elizabeth J.^11,14  Pichler, Werner J.¹⁵  Platts-Mills, Thomas A. E.¹⁶  Roujeau, Jean-Claude¹⁷  Schwartz, Lawrence B.¹⁸  Trepanier, Lauren A.¹⁹ 

[1] NIAID, Div Allergy Immunol & Transplantat, NIH, Rockville, MD 20852 USA

[2] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02114 USA

[3] Brigham & Womens Hosp, Dept Med, Div Rheumatol Immunol & Allergy, Drug Hypersensit & Desensitizat Ctr, Boston, MA 02115 USA

[4] Univ Cincinnati, Div Allergy Immunol & Rheumatol, Dept Internal Med, Coll Med,Dept Med,Cincinnati Vet Affairs Med Ctr, Cincinnati, OH 45221 USA

[5] Cincinnati Childrens Hosp Med Ctr, Div Immunobiol, Cincinnati, OH 45229 USA

[6] Univ Utah, Dept Dermatol, Salt Lake City, UT USA

[7] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA

[8] Mt Sinai Med Ctr, Dept Dermatol, New York, NY 10029 USA

[9] Mt Sinai Med Ctr, Inst Immunol, Icahn Sch Med, New York, NY 10029 USA

[10] Vanderbilt Univ, Sch Med, Dept Med, Ctr Translat Immunol & Infect Dis, Nashville, TN 37212 USA

[11] Murdoch Univ, Inst Immunol & Infect Dis, Murdoch, WA 6150, Australia

[12] Univ Liverpool, Dept Pharmacol, MRC, Ctr Drug Safety Sci, Liverpool L69 3BX, Merseyside, England

[13] Univ Florida, Coll Med, Div Expt Pathol, Dept Pathol Immunol & Lab Med, Gainesville, FL USA

[14] Vanderbilt Univ, Med Ctr, Dept Med, Div Infect Dis, Nashville, TN USA

[15] ADR AC GMBH, CH-3008 Bern, Switzerland

[16] Univ Virginia, Dept Med, Asthma & Allerg Dis Ctr, Charlottesville, VA USA

[17] Univ Paris Est Creteil, F-94010 Creteil, France

[18] Virginia Commonwealth Univ, Dept Internal Med, Div Rheumatol Allergy & Immunol, Richmond, VA 23284 USA

[19] Univ Wisconsin Madison, Sch Vet Med, Dept Med Sci, Madison, WI USA

关键词: Drug allergy;    drug hypersensitivity;    desensitization;    pharmacogenomics;    Stevens-Johnson syndrome;    toxic epidermal necrolysis;    hapten hypothesis;    altered peptide repertoire hypothesis;    pharmacologic interaction with immune receptor hypothesis;   

DOI  :  10.1016/j.jaci.2015.05.027

来源: Elsevier

【 摘 要 】

Allergic reactions to drugs are a serious public health concern. In 2013, the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology, and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several National Institutes of Health institutes and the US Food and Drug Administration. The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein.

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