Prenatal oxidative balance and risk of asthma and allergic disease in adolescence

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:144

Article

Sordillo, Joanne E.^1,2  Rifas-Shiman, Sheryl L.^1,2  Switkowski, Karen^1,2  Coull, Brent³  Gibson, Heike³  Rice, Mary⁴  Platts-Mills, Thomas A. E.⁵  Kloog, Itai⁷  Litonjua, Augusto A.⁶  Gold, Diane R.^7,8  Oken, Emily^1,2 

[1] Harvard Med Sch, Dept Populat Med, Div Chron Dis Res Lifecourse CoRAL, Boston, MA 02115 USA

[2] Harvard Pilgrim Hlth Care Inst, Boston, MA USA

[3] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA

[4] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA

[5] Beth Israel Deaconess Med Ctr, Dept Med, Div Pulm Crit Care & Sleep Med, Boston, MA 02215 USA

[6] Univ Virginia Hlth Syst, Asthma & Allerg Dis Ctr, Charlottesville, VA USA

[7] Univ Rochester, Med Ctr, Div Pediat Pulm Med, Rochester, NY 14642 USA

[8] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA

关键词: Asthma;    allergic sensitization;    nutrients;    air pollution;    oxidative balance;    antioxidants;    pro-oxidants;    oxidative stress;   

DOI  :  10.1016/j.jaci.2019.07.044

来源: Elsevier

【 摘 要 】

Background: Fetal oxidative balance (achieved when protective prenatal factors counteract sources of oxidative stress) might be critical for preventing asthma and allergic disease. Objective: We examined prenatal intakes of hypothesized protective nutrients (including antioxidants) in conjunction with potential sources of oxidative stress in models of adolescent asthma and allergic disease. Methods: We used data from 996 mother-child pairs in Project Viva. Exposures of interest were maternal prepregnancy body mass index and prenatal nutrients (energy-adjusted intakes of vitamins D, C, and E; beta-carotene; folate; choline; and n-3 and n-6 polyunsaturated fatty acids [PUFAs]), air pollutant exposures (residence-specific third-trimester black carbon or particulate matter with a diameter of less than 2.5 mm [PM2.5]), acetaminophen, and smoking. Outcomes were offspring's current asthma, allergic rhinitis, and allergen sensitization at a median age of 12.9 years. We performed logistic regression. Continuous exposures were log-transformed and modeled as z scores. Results: We observed protective associations for vitamin D (odds ratio [OR], 0.69 [95% CI, 0.53-0.89] for allergic rhinitis), the sum of the n-3 PUFAs eicosapentaenoic acid and docosahexaenoic acid (OR, 0.81 [95% CI, 0.66-0.99] for current asthma), and the n-3 PUFA alpha-linolenic acid (OR, 0.78 [95% CI, 0.64-0.95] for allergen sensitization and OR, 0.80 [95% CI 0.65-0.99] for current asthma). Black carbon and PM2.5 were associated with an approximately 30% increased risk for allergen sensitization. No multiplicative interactions were observed for protective nutrient intakes with sources of oxidative stress. Conclusions: We identified potential protective prenatal nutrients (vitamin D and n-3 PUFAs), as well as adverse prenatal pro-oxidant exposures that might alter the risk of asthma and allergic disease into adolescence.

【 授权许可】

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