Recommendations for appropriate sublingual immunotherapy clinical trials

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:124

Article

Casale, Thomas B.¹  Canonica, G. Walter³  Bousquet, Jean^2,4  Cox, Linda⁵  Lockey, Richard⁶  Nelson, Harold S.⁷  Passalacqua, Giovanni³ 

[1] Creighton Univ, Omaha, NE 68131 USA

[2] Hop Arnaud Villeneuve, Montpellier, France

[3] Univ Genoa, I-16126 Genoa, Italy

[4] Inst Natl Santi & Rech Midicale, U780, Montpellier, France

[5] Nova SE Univ, Sch Osteopath Med, Davie, FL USA

[6] Univ S Florida, Tampa, FL USA

[7] Natl Jewish Hlth, Denver, CO USA

关键词: Immunotherapy;    sublingual immunotherapy;    subcutaneous immunotherapy;    allergic rhinitis;    allergic conjunctivitis;    allergic asthma;   

DOI  :  10.1016/j.jaci.2009.07.054

来源: Elsevier

【 摘 要 】

Sublingual immunotherapy is gaining widespread attention as a viable alternative to subcutaneous immunotherapy for the treatment of allergic rhinoconjunctivitis. In addition, sublingual immunotherapy has been studied in other allergic disorders including asthma. However, a review of published studies indicates that there are deficiencies and considerable heterogeneity in both design and data interpretation of sublingual immunotherapy studies. These deficiencies have made it somewhat difficult to assess the appropriate place of sublingual immunotherapy in guidelines for the therapy of allergic diseases. Moreover, several unpublished oral and sublingual immunotherapy studies in the United States failed to meet primary endpoints. This article reviews data from sublingual immunotherapy trials and makes recommendations about appropriate designs of future sublingual immunotherapy studies. It is hoped that these recommendations will result in more adequately designed sublingual immunotherapy trials to facilitate the appropriate placement of this therapy to treat patients with allergic rhinoconjunctivitis and other allergic diseases. (J Allergy Clin Immunol 2009;124:665-70.)

【 授权许可】

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