Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:115

Article

Ponikau, JU ; Sherris, DA ; Weaver, A ; Kita, H

关键词: eosinophils;    antifungal;    chronic sinusitis;    nasal polyps;    chronic rhinosinusitis;    amphotericin B;   

DOI  :  10.1016/j.jaci.2004.09.037

来源: Elsevier

【 摘 要 】

Background: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. Its etiology is unknown, and there is a paucity of effective medical treatments. Objective: We tested the hypothesis that intranasal antifungal treatment improves the objective computed tomography (CT) findings (inflammatory mucosal thickening), nasal endoscopy stages, and symptoms of CRS. Methods: A randomized, placebo-controlled, double-blind, single-center trial used amphotericin B to treat 30 randomly selected patients with CRS. Patients were instructed to instill 20 mL amphotericin B (250 mug/mL) or placebo to each nostril twice daily for 6 months. The primary outcome was a quantitative reduction in inflammatory mucosal thickening on CT scans of a standardized coronal cut. Secondary outcome measures were endoscopic scores, patient symptom scores, and levels of intranasal inflammatory mediators. Results: Twenty-four patients completed the 6 months of treatment. Patients receiving amphotericin B achieved a relative reduction in the percentage of mucosal thickening on CT scans (n = 10; -8.8%) compared with placebo (n = 14; +2.5%; P=.030). Likewise, the changes in the endoscopic scores improved in the amphotericin B group compared with placebo (P =.038). Between-group comparisons of the changes in the intranasal mucus levels of eosinophil-derived neurotoxin showed a reduction in the amphotericin B group and an increase in the placebo group (P =.046); levels of IL-5 showed similar tendencies (P =.082). Conclusion: Intranasal amphotericin B reduced inflammatory mucosal thickening on both CT scan and nasal endoscopy and decreased. the levels of intranasal markers for eosinophilic inflammation in patients with CRS.

【 授权许可】

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