Clinical and pathologic perspectives on aspirin sensitivity and asthma

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:118

Review

Stevenson, Donald D. ; Szczeklik, Andrew

关键词: aspirin;    nonsteroidal anti-inflammatory drugs;    asthma;    nasal polyps;    chronic hyperplastic eosinophilic sinusitis;    aspirin-exacerbated respiratory disease;    aspirin desensitization;   

DOI  :  10.1016/j.jaci.2006.07.024

来源: Elsevier

【 摘 要 】

Aspirin and other nonsteroidal anti-inflammatory drugs that inhibit COX-1 induce unique nonallergic reactions, consisting of attacks of rhinitis and asthma. These hypersensitivity reactions occur in a subset of asthmatic subjects, thus identifying them as having this exclusive clinical presentation. We refer to these patients as having aspirin-exacerbated respiratory disease, a disease process that produces devastating eosinophilic inflammation of both the upper and lower respiratory tracts. This review focuses on a description of patients with aspirin-exacerbated respiratory disease, methods available to diagnose their condition, the unique ability of all nonsteroidal anti-inflammatory drugs that inhibit COX-1 to cross-react with aspirin, an update on pathogenesis, and current thoughts about treatment.

【 授权许可】

Free