Advances in mechanisms of allergic disease in 2016

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:140

Article

Rothenberg, Marc E.¹  Saito, Hirohisa²  Peebles, R. Stokes, Jr.³ 

[1] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Allergy & Immunol, Cincinnati, OH 45229 USA

[2] Natl Res Inst Child Hlth & Dev, Tokyo, Japan

[3] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA

关键词: Allergy;    immunology;    innate;    inflammation;    food allergy;    asthma;    mast cell;    eosinophil;    ozone;    IL-33;    extracellular vesicles;   

DOI  :  10.1016/j.jaci.2017.08.029

来源: Elsevier

【 摘 要 】

This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells; T(H)2 lymphocytes; eicosanoid regulation of inflammation; extracellular vesicles in allergic responses; IL-33; microbiome properties, especially as they relate to mucosal barrier function; and a series of findings concerning the allergic inflammatory cells eosinophils, basophils, and mast cells. During the last year, mechanistic advances occurred in understanding type 2 innate lymphoid cells, particularly related to their response to ozone, involvement with experimental food allergy responses, and regulation by IL-33. Novel ways of regulating T(H)2 cells through epigenetic regulation of GATA-3 through sirtuin-1, a class III histone deacetylase, were published. The understanding of eicosanoid regulation of inflammation increased and focused on additional properties of phospholipase A(2) and the role of prostaglandin D-2 and its receptors and inhibitory prostaglandin E-2 pathways. Mechanisms through which extracellular vesicles are released and contribute to allergic responses were reported. There was a deeper appreciation of mucosal barrier function, the epithelial alarmin IL-33, and the microbiome. Finally, there were advances concerning allergic inflammatory cells (mast cells, basophils, and eosinophils) that will undoubtedly have an effect on disease understanding and new therapeutic strategies.

【 授权许可】

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