CLINICAL CORRELATION OF THE VENOM-SPECIFIC IGG ANTIBODY LEVEL DURING MAINTENANCE VENOM IMMUNOTHERAPY

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:90

Article

关键词: INSECT-STING ALLERGY;    VENOM;    ANAPHYLAXIS;    IMMUNOTHERAPY;    IGG ANTIBODIES;    HYMENOPTERA;   

DOI  :  10.1016/S0091-6749(05)80019-3

来源: Elsevier

【 摘 要 】

Allergen immunotherapy is associated with a significant increase of specific IgG antibodies that have been suggested as a mechanism of action and as a marker of efficacy for immunotherapy. The value of venom-specific IgG antibody determinations as a measure of clinical protection against sting anaphylaxis has been difficult to prove in individual patients. We performed 211 insect sting challenges in 109 patients over a 4-year period to determine the significance of venom IgG levels 3 mug/ml or lower. Systemic symptoms occurred in only 1.6% of those with venom IgG more than 3 mug/ml, but in 16% of those with less than 3 mug/ml IgG, and notably in 26% of patients with low venom IgG who had received less than 4 years of treatment. The venom IgG level had no predictive value in patients who had received more than 4 years of therapy. Honeybee sting data were inconclusive because of the small number of subjects. We conclude that low venom-specific IgG levels are associated with an elevated risk of treatment failure during the first 4 years of immunotherapy with yellow jacket or mixed vespid venoms.

【 授权许可】

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