An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:123

Article

Marenholz, Ingo²  Kerscher, Tamara²  Bauerfeind, Anja²  Esparza-Gordillo, Jorge²  Keil, Thomas¹  Rohde, Klaus²  Lee, Young-Ae^1,2 

[1] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany

[2] Max Delbruck Ctr Mol Med, Berlin, Germany

关键词: Genetic prediction;    interaction;    asthma;    eczema;    food sensitization;    filaggrin;    mutations;    subphenotype;    prevention;    pulmonary function;   

DOI  :  10.1016/j.jaci.2009.01.051

来源: Elsevier

【 摘 要 】

Background: Asthma prediction in early infancy is essential for the development of new preventive strategies. Loss-of-function mutations in the filaggrin gene (FLG) were identified as risk factors for eczema and associated asthma. Objective: We evaluated the utility of the FLG mutations for the prediction of asthma. Methods: Eight hundred seventy-one individuals of the prospective German Multicenter Allergy Study cohort were genotyped for 3 FLG mutations. Information on asthma, eczema, and food sensitization was available from birth to 13 years of age. Pulmonary function was measured from 7 to 13 years of age. The predictive value of the FLG mutations and of atopic phenotypes in infancy was assessed for asthma. Results: In infants with eczema and sensitization to food allergens, the FLG mutations predicted childhood asthma with a positive predictive value of 100% (95% CI, 65.5% to 100%). This subgroup was characterized by a significant decrease in pulmonary function until puberty and represented 8.1% of all asthmatic children and 19.1% of patients with asthma after infantile eczema. We found a strong synergistic interaction between the FLG-null alleles and early food sensitization in the disease transition from eczema to asthma (relative excess risk due to interaction, 2.64; 95% CI, 1.70-3.98; P = .00040). Conclusion: FLG mutations and food sensitization represent 2 distinct mechanisms interacting in the pathogenesis of asthma. In infants with eczema and food sensitization, genotyping of the FLG mutations allows the prediction of asthma before the onset of symptoms. Our findings might facilitate the development of early subgroup-specific interventions to prevent the progression from eczema to asthma. (J Allergy Clin Immunol 2009;123:911-6.)

【 授权许可】

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