Allergy to furry animals: New insights, diagnostic approaches, and challenges

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:135

Article

Konradsen, Jon R.^1,2,3  Fujisawa, Takao⁴  van Hage, Marianne^5,6  Hedlin, Gunilla^1,2,3  Hilger, Christiane⁷  Kleine-Tebbe, Joerg⁸  Matsui, Elizabeth C.⁹  Roberts, Graham^10,11,12,13  Ronmark, Eva¹⁴  Platts-Mills, Thomas A. E.¹⁵ 

[1] Karolinska Inst, Dept Womens & Childrens Hlth, S-10401 Stockholm, Sweden

[2] Karolinska Inst, Ctr Allergy Res, S-10401 Stockholm, Sweden

[3] Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, SE-17176 Stockholm, Sweden

[4] Mie Natl Hosp, Inst Clin Res, Tsu, Mie, Japan

[5] Karolinska Inst, Clin Immunol & Allergy Unit, Dept Med, Stockholm, Sweden

[6] St Gorans Univ Hosp, S-11281 Stockholm, Sweden

[7] CRP Sante, Lab Immunogenet & Allergol, Luxembourg, Luxembourg

[8] Allergy & Asthma Ctr Westend, Outpatient Clin & Res Unit, Berlin, Germany

[9] Johns Hopkins Sch Med, Div Pediat Allergy Immunol, Baltimore, MD USA

[10] St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Isle Of Wight, England

[11] Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton SO9 5NH, Hants, England

[12] Univ Southampton, Fac Med, Clin & Expt Sci Acad Unit, Southampton SO9 5NH, Hants, England

[13] Univ Hosp Southampton NHS Fdn Trust, NIHR Resp Biomed Res Unit, Southampton, Hants, England

[14] Umea Univ, Dept Publ Hlth & Clin Med, Occupat & Environm Med, S-90187 Umea, Sweden

[15] Univ Virginia, Asthma & Allerg Dis Ctr, Charlottesville, VA USA

关键词: Molecular-based allergy diagnostics;    allergy;    allergens;    furry animals;    cats;    dogs;    allergic asthma;    allergic rhinitis;    pork-cat syndrome;   

DOI  :  10.1016/j.jaci.2014.08.026

来源: Elsevier

【 摘 要 】

The prevalence of allergy to furry animals has been increasing, and allergy to cats, dogs, or both is considered a major risk factor for the development of asthma and rhinitis. An important step forward in the diagnosis of allergy to furry animals has been made with the introduction of molecular-based allergy diagnostics. A workshop on furry animals was convened to provide an up-to-date assessment of our understanding of (1) the exposure and immune response to the major mammalian allergens, (2) the relationship of these responses (particularly those to specific proteins or components) to symptoms, and (3) the relevance of these specific antibody responses to current or future investigation of patients presenting with allergic diseases. In this review research results discussed at the workshop are presented, including the effect of concomitant exposures from other allergens or microorganisms, the significance of the community prevalence of furry animals, molecular-based allergy diagnostics, and a detailed discussion of cat and dog components.

【 授权许可】

Free