Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:130

Article

Li, Xingnan¹  Ampleford, Elizabeth J.¹  Howard, Timothy D.¹  Moore, Wendy C.¹  Torgerson, Dara G.⁸  Li, Huashi¹  Busse, William W.²  Castro, Mario^3,4  Erzurum, Serpil C.⁵  Israel, Elliot⁶  Nicolae, Dan L.⁸  Ober, Carole⁸  Wenzel, Sally E.⁷  Hawkins, Gregory A.¹  Bleecker, Eugene R.¹  Meyers, Deborah A.¹ 

[1] Wake Forest Univ, Bowman Gray Sch Med, Ctr Genom & Personalized Med Res, Winston Salem, NC 27157 USA

[2] Univ Wisconsin, Dept Med, Madison, WI USA

[3] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[5] Lerner Res Inst, Cleveland, OH USA

[6] Harvard Univ, Brigham & Womens Hosp, Boston, MA 02115 USA

[7] Univ Pittsburgh, Dept Med, Pittsburgh, PA 15260 USA

[8] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

关键词: Asthma;    genetics;    genome-wide association study;    TNFAIP3 interacting protein 1;   

DOI  :  10.1016/j.jaci.2012.04.041

来源: Elsevier

【 摘 要 】

Background: Genome-wide association studies (GWASs) of asthma have consistently implicated the ORM1-like 3 and gasdermin B (ORMDL3-GSDMB), IL33, IL-1 receptor-like 1 and IL-18 receptor 1 (IL1RL1-IL18R1), RAD50-IL13, thymic stromal lymphopoietin and WD repeat domain 36 region (TSLP-WDR36), and HLA-DR/DQ regions. Objective: A GWAS of asthma was performed in a non-Hispanic white population. Methods: A GWAS was performed in 813 Severe Asthma Research Program/Collaborative Studies on the Genetics of Asthma/Chicago Asthma Genetics Study cases and 1564 control subjects. The GWAS results were compared with those of the published GWASs of autoimmune diseases. Results: Multiple single nucleotide polymorphisms in the TNFAIP3 interacting protein 1 (TNIP1) gene, which interacts with TNFAIP3 and inhibits the TNF-alpha-induced nuclear factor kappa B inflammation pathway, were associated with asthma: rs1422673 (P = 3.44 x 10(-7)) and rs10036748 (P = 1.41 x 10(-6), r(2) = 0.67). rs1422673 was also associated with asthma in the published GABRIEL (P = .018) and EVE (P = 1.31 x 10(-5)) studies. The minor allele Tof rs20541 in IL13 is the risk allele for asthma but the protective allele for psoriasis. The minor allele Tof rs2395185 in HLA-DRA is the risk allele for asthma but the protective allele for ulcerative colitis. The minor allele A of rs2872507 in GSDMB is the protective allele for asthma but the risk allele for rheumatoid arthritis, Crohn disease, and ulcerative colitis. The T allele of rs10036748 in the TNIP1 gene is the minor protective allele for asthma but the minor or major risk allele for systemic lupus erythematosus and systemic sclerosis in non-Hispanic white or Chinese subjects, respectively. Conclusions: Our study suggests that single nucleotide polymorphisms associated with both asthma and autoimmune diseases might have opposite effects on immunopathogenesis. (J Allergy Clin Immunol 2012; 130:861-8.)

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