The Wiskott-Aldrich syndrome

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:117

Review

Ochs, HD ; Thrasher, AJ

关键词: Wiskott-Aldrich syndrome;    X-linked thrombocytopenia;    X-linked neutropenia;    function of WASP;    immune defects;    scoring system;    mutation analysis;    mutational hotspots;    genotype-phenotype correlation;    hematopoietic stem cell transplantation;    gene therapy;   

DOI  :  10.1016/j.jaci.2006.02.005

来源: Elsevier

【 摘 要 】

The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder with variable clinical phenotypes that correlate with the type or mutations in the WAS protein (WASP) gene. WASP, a key regulator of actin polymerization in hematopoietic cells, has 5 well-defined domains that are involved in signaling, cell locomotion, and immune synapse formation. WASP facilitates the nuclear translocation of nuclear factor kappa B and was shown to play an important role in lymphoid development and in the maturation and function of myeloid monocytic cells. Mutations of WASP are located throughout the gene and either inhibit or dysregulate normal WASP function. Analysis of a large patient population demonstrates a phenotype-genotype correlation: classic WAS occurs when WASP is absent, X-linked thrombocytopenia when mutated WASP is expressed, and X-linked neutropenia when missense mutations occur in the Cdc42-binding site. The progress made in dissecting the function of WASP has provided new diagnostic possibilities and has propelled our therapeutic strategies from conservative symptomatic treatment to curative hematopoietic stem cell transplantation and toward gene therapy.

【 授权许可】

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