Proceedings from the Inaugural American Initiative in Mast Cell Diseases(AIM) Investigator Conference

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:147

Review

Gotlib, Jason¹  George, Tracy I.²  Carter, Melody C.³  Austen, K. Frank⁴  Bochner, Bruce⁵  Dwyer, Daniel F.⁴  Lyons, Jonathan J.³  Hamilton, Matthew J.⁶  Butterfield, Joseph⁷  Bonadonna, Patrizia⁸  Weiler, Catherine⁷  Galli, Stephen J.^9,10  Schwartz, Lawrence B.¹¹  Elberink, Hanneke Oude¹²  Maitland, Anne¹³  Theoharides, Theoharis¹⁴  Ustun, Celalettin¹⁵  Horny, Hans-Peter¹⁶  Orfao, Alberto^17,18  Deininger, Michael^19,20  Radia, Deepti²¹  Jawhar, Mohamad²²  Kluin-Nelemans, Hanneke²³  Metcalfe, Dean D.³  Arock, Michel²⁴  Sperr, Wolfgang R.^25,26  Valent, Peter^25,26  Castells, Mariana^27,28  Akin, Cem²⁹ 

[1] Stanford Univ, Sch Med, Div Hematol, Stanford Canc Inst, Stanford, CA 94305 USA

[2] Univ Utah, Sch Med, Dept Pathol, Salt Lake City, UT USA

[3] NIAID, Lab Allerg Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[4] Brigham & Womens Hosp, Dept Med, Div Rheumatol Immunol & Allergy, 75 Francis St, Boston, MA 02115 USA

[5] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Allergy & Immunol, Chicago, IL 60611 USA

[6] Harvard Med Sch, Brigham & Womens Hosp, Div Gastroenterol Hepatol & Endoscopy, Boston, MA 02115 USA

[7] Mayo Clin, Div Allerg Dis, Rochester, MN USA

[8] Verona Univ Hosp, Allergy Unit, Verona, Italy

[9] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[10] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[11] Virginia Commonwealth Univ, Dept Internal Med, Div Rheumatol Allergy & Immunol, Richmond, VA USA

[12] Univ Groningen, Univ Med Ctr Groningen, Sect Allergol, Internal Med, Groningen, Netherlands

[13] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA

[14] Tufts Univ, Sch Med, Dept Immunol, Boston, MA 02111 USA

[15] Rush Univ, Dept Med, Div Hematol Oncol & Cellular Therapy, Chicago, IL 60612 USA

[16] Ludwig Maximilians Univ Munchen, Inst Pathol, Munich, Germany

[17] Univ Salamanca, Serv Cent Citometria, Ctr Invest Canc IBMCC CSIC USAL, IBSAL,CIBERONC, Salamanca, Spain

[18] Univ Salamanca, Dept Med, Salamanca, Spain

[19] Univ Utah, Div Hematol & Hematol Malignancies, Salt Lake City, UT USA

[20] Huntsman Canc Inst, Salt Lake City, UT USA

[21] Guys & St Thomas NHS Hosp, Dept Clin Haematol, London, England

[22] Heidelberg Univ, Univ Hosp Mannheim, Heidelberg, Germany

[23] Univ Groningen, Univ Med Ctr Groningen, Dept Haematol, Groningen, Netherlands

[24] Hop La Pitie Salpetriere, Haematol Lab, Paris, France

[25] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, Vienna, Austria

[26] Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria

[27] Brigham & Womens Hosp, Div Allergy & Clin Immunol, 75 Francis St, Boston, MA 02115 USA

[28] Harvard Med Sch, Boston, MA 02115 USA

[29] Univ Michigan, Div Allergy & Immunol, Ann Arbor, MI 48109 USA

关键词: Systemic mastocytosis;    siglec-8;    mast cell activation syndrome;    hereditary alpha-tryptasemia;    anaphylaxis;    European Competence Network on Mastocytosis (ECNM);    American Initiative in Mast Cell Diseases (AIM);   

DOI  :  10.1016/j.jaci.2021.03.008

来源: Elsevier

【 摘 要 】

The American Initiative in Mast Cell Diseases (AIM) held its inaugural investigator conference at Stanford University School of Medicine in May 2019. The overarching goal of this meeting was to establish a Pan-American organization of physicians and scientists with multidisciplinary expertise in mast cell disease. To serve this unmet need, AIM envisions a network where basic, translational, and clinical researchers could establish collaborations with both academia and biopharma to support the development of new diagnostic methods, enhanced understanding of the biology of mast cells in human health and disease, and the testing of novel therapies. In these AIM proceedings, we highlight selected topics relevant to mast cell biology and provide updates regarding the recently described hereditary alpha-tryptasemia. In addition, we discuss the evaluation and treatment of mast cell activation (syndromes), allergy and anaphylaxis in mast cell disorders, and the clinical and biologic heterogeneity of the more indolent forms of mastocytosis. Because mast cell disorders are relatively rare, AIM hopes to achieve a coordination of scientific efforts not only in the Americas but also in Europe by collaborating with the well-established European Competence Network on Mastocytosis.

【 授权许可】

Free