Update on allergies in pregnancy, lactation, and early childhood

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:123

Article

Pali-Schoell, Isabella¹  Renz, Harald² 

[1] Med Univ Vienna, Dept Pathophysiol, Ctr Physiol Pathophysiol & Immunol, A-1090 Vienna, Austria

[2] Hosp Philipps Univ Marburg, Dept Clin Chem & Mol Diagnost, Marburg, Germany

关键词: Allergy;    pregnancy;    lactation;    atopy;    newborn;    acid-suppression;    prevention;   

DOI  :  10.1016/j.jaci.2009.01.045

来源: Elsevier

【 摘 要 】

The factors responsible for the induction of allergic disease at an early age have not been completely identified. Therefore a major research focus is their identification to elaborate recommendations for prevention of sensitization in high-risk or atopic children. This review analyzes known or suspected reasons for sensitization in pregnant women and infants from both clinical and experimental animal studies. Recent studies and meta-analyses could not confirm the protective effect of an allergen-poor diet on the part of the mother during pregnancy and lactation. Likewise, the type of bottle feeding or the introduction of solid food into the child's diet might not significantly influence the development of atopy, allergy, or asthma in the child's life. Disappointingly, the few preventive measures remaining to reduce the risk of allergic sensitization and atopic diseases in mother and child are the avoidance of smoking and alcohol consumption during pregnancy and lactation and the avoidance of the impairment of gastric function. Further studies are urgently needed to address the influence of certain foods and nutrients, as well as environmental factors, for prevention of allergic diseases in the low- or high-risk infant. (J Allergy Clin Immunol 2009;123:1012-21.)

【 授权许可】

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